› 3m98

X-ray diffraction
1.5Å resolution

Crystal structure of human carbonic anhydrase isozyme II with 5-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide

Released:
DOI: 10.2210/pdb3m98/pdb
PDB entry 3m98 coloured by chain, front view.
PDB entry 3m98 coloured by chain, side view.
PDB entry 3m98 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Grazulis S, Manakova E, Golovenko D

Function and Biology Details

Reactions catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Urea = cyanamide + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133681 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

4 bound ligands:
Ligand ZN 1 x ZN
Ligand E02 1 x E02
Ligand MES 1 x MES
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P21
Unit cell:
a: 42.233Å b: 41.112Å c: 72.109Å
α: 90° β: 104.05° γ: 90°
R-values:
R R work R free
0.14 0.135 0.184
Expression system: Escherichia coli

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