› 3mw4

X-ray diffraction
2Å resolution

Crystal structure of beta-neurexin 3 without the splice insert 4

Released:
DOI: 10.2210/pdb3mw4/pdb
PDB entry 3mw4 coloured by chain, front view.
PDB entry 3mw4 coloured by chain, side view.
PDB entry 3mw4 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Splice form dependence of beta-neurexin/neuroligin binding interactions.
Koehnke J, Katsamba PS, Ahlsen G, Bahna F, Vendome J, Honig B, Shapiro L, Jin X
Neuron 67 61-74 (2010)
PMID: 20624592

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-564328 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Neurexin-3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 178 amino acids
Theoretical weight: 19.39 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P9K9 (Residues: 1090-1293; Coverage: 11%)
Gene name: Nrxn3
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand CA 1 x CA
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P212121
Unit cell:
a: 74.714Å b: 83.398Å c: 119.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.215
Expression system: Homo sapiens

Quick links

Citations

18 review citations

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders.
Gao et al. (2015)
17 more

2 mentions without citation

Neurexins - versatile molecular platforms in the synaptic cleft.
Rudenko G. (2019)
1 more