› 3osw

X-ray diffraction
2.55Å resolution

Crystal structure of PPARgamma ligand binding domain in complex with tetrabromo-bisphenol A (TBBPA)

Released:
DOI: 10.2210/pdb3osw/pdb
PDB entry 3osw coloured by chain, front view.
PDB entry 3osw coloured by chain, side view.
PDB entry 3osw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A.
Riu A, Grimaldi M, le Maire A, Bey G, Phillips K, Boulahtouf A, Perdu E, Zalko D, Bourguet W, Balaguer P
OpenAccess logo Environ Health Perspect 119 1227-32 (2011)
PMID: 21561829

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 285 amino acids
Theoretical weight: 32.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 224-504; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand XDI 1 x XDI
Ligand PGO 1 x PGO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 93.089Å b: 61.693Å c: 118.458Å
α: 90° β: 102.75° γ: 90°
R-values:
R R work R free
0.195 0.193 0.251
Expression system: Escherichia coli

Quick links

Citations

41 review citations

Review: Endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms.
Rogers et al. (2013)
40 more

2 mentions without citation

Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism.
Kroker et al. (2015)
1 more