› 3poy

X-ray diffraction
3.02Å resolution

Crystal Structure of the alpha-Neurexin-1 ectodomain, LNS 2-6

Released:
DOI: 10.2210/pdb3poy/pdb
PDB entry 3poy coloured by chain, front view.
PDB entry 3poy coloured by chain, side view.
PDB entry 3poy coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function.
Miller MT, Mileni M, Comoletti D, Stevens RC, Harel M, Taylor P
Structure 19 767-78 (2011)
PMID: 21620717

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173308 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Neurexin-1 Chain: A
Molecule details ›
Chain: A
Length: 1019 amino acids
Theoretical weight: 112.59 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q28146 (Residues: 296-1349; Coverage: 67%)
  • Best match: Q28146-11 (Residues: 296-1319)
Gene name: NRXN1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand BGC 1 x BGC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 199.74Å b: 61.24Å c: 155.58Å
α: 90° β: 121.21° γ: 90°
R-values:
R R work R free
0.216 0.214 0.269
Expression system: Homo sapiens

Quick links

Citations

8 review citations

The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses.
Krueger et al. (2012)
7 more

14 mentions without citation

Neurexins: molecular codes for shaping neuronal synapses.
Gomez et al. (2021)
13 more