› 3pzd

X-ray diffraction
2.5Å resolution

Structure of the myosin X MyTH4-FERM/DCC complex

Released:
DOI: 10.2210/pdb3pzd/pdb
PDB entry 3pzd coloured by chain, front view.
PDB entry 3pzd coloured by chain, side view.
PDB entry 3pzd coloured by chain, top view.
Source organisms:
Primary publication:
Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain.
Wei Z, Yan J, Lu Q, Pan L, Zhang M
Proc Natl Acad Sci U S A 108 3572-7 (2011)
PMID: 21321230

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159717 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Unconventional myosin-X Chain: A
Molecule details ›
Chain: A
Length: 511 amino acids
Theoretical weight: 58.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HD67 (Residues: 1503-2047; Coverage: 25%)
Gene names: KIAA0799, MYO10
Sequence domains:
Structure domains:
Netrin receptor DCC Chain: B
Molecule details ›
Chain: B
Length: 36 amino acids
Theoretical weight: 3.94 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P70211 (Residues: 1410-1445; Coverage: 3%)
Gene name: Dcc

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 85.167Å b: 49.528Å c: 92.814Å
α: 90° β: 112.58° γ: 90°
R-values:
R R work R free
0.206 0.203 0.259
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Myosin-X: a MyTH-FERM myosin at the tips of filopodia.
Kerber et al. (2011)
7 more

7 mentions without citation

Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain.
Wei et al. (2011)
6 more