› 3qlm

X-ray diffraction
2.5Å resolution

Crystal structure of porcine pancreatic phospholipase A2 in complex with n-hexadecanoic acid

Released:
DOI: 10.2210/pdb3qlm/pdb
PDB entry 3qlm coloured by chain, front view.
PDB entry 3qlm coloured by chain, side view.
PDB entry 3qlm coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Anti-inflammatory property of n-hexadecanoic acid: structural evidence and kinetic assessment.
Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasivan C, Haridas M
Chem Biol Drug Des 80 434-9 (2012)
PMID: 22642495

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospholipase A2, major isoenzyme Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.01 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P00592 (Residues: 23-146; Coverage: 95%)
Gene name: PLA2G1B
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand PLM 1 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P3121
Unit cell:
a: 69.26Å b: 69.26Å c: 69.66Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.191 0.249

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Citations

5 review citations

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient.
Chen et al. (2021)
4 more