› 3r69

X-ray diffraction
1.5Å resolution

Molecular analysis of the interaction of the HDL-receptor SR-BI with the PDZ3 domain of its adaptor protein PDZK1

Released:
DOI: 10.2210/pdb3r69/pdb
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PDB entry 3r69 coloured by chain, front view.
PDB entry 3r69 coloured by chain, side view.
PDB entry 3r69 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Identification of the PDZ3 domain of the adaptor protein PDZK1 as a second, physiologically functional binding site for the C terminus of the high density lipoprotein receptor scavenger receptor class B type I.
Kocher O, Birrane G, Yesilaltay A, Shechter S, Pal R, Daniels K, Krieger M
J Biol Chem 286 25171-86 (2011)
PMID: 21602281

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-191607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 89 amino acids
Theoretical weight: 9.41 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JIL4 (Residues: 241-323; Coverage: 16%)
Gene names: Cap70, Nherf3, Pdzk1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P212121
Unit cell:
a: 47.638Å b: 61.396Å c: 64.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.225
Expression system: Escherichia coli

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Citations

5 review citations

Structure, regulation, and functional diversity of microvilli on the apical domain of epithelial cells.
Sauvanet et al. (2015)
4 more

5 mentions without citation

Electric-field-stimulated protein mechanics.
Hekstra et al. (2016)
4 more

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