› 3t49

X-ray diffraction
1.45Å resolution

Crystal structure of truncated form of Staphylococcal Complement Inhibitor B (SCIN-B) at 1.5 Angstrom

Released:
DOI: 10.2210/pdb3t49/pdb
Model geometry
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PDB entry 3t49 coloured by chain, front view.
PDB entry 3t49 coloured by chain, side view.
PDB entry 3t49 coloured by chain, top view.
Source organism: Staphylococcus aureus subsp. aureus Mu50
Primary publication:
Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family.
Garcia BL, Summers BJ, Lin Z, Ramyar KX, Ricklin D, Kamath DV, Fu ZQ, Lambris JD, Geisbrecht BV
J Biol Chem 287 628-640 (2012)
PMID: 22086928

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102007 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Staphylococcal complement inhibitor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 73 amino acids
Theoretical weight: 8.21 KDa
Source organism: Staphylococcus aureus subsp. aureus Mu50
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0H3JZ23 (Residues: 49-116; Coverage: 72%)
Gene name: SAV1159
Sequence domains: Staphylococcal complement inhibitor SCIN
Structure domains: Substrate Binding Domain Of Dnak; Chain:A; Domain 2

Ligands and Environments

2 bound ligands:
Ligand GOL 4 x GOL
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 44.668Å b: 66.937Å c: 60.407Å
α: 90° β: 95.22° γ: 90°
R-values:
R R work R free
0.142 0.141 0.166
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Novel Evasion Mechanisms of the Classical Complement Pathway.
Garcia et al. (2016)
2 more

2 mentions without citation

Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family.
Garcia et al. (2012)
1 more

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