› 3umr

X-ray diffraction
2.04Å resolution

Crystal structure of the G202D mutant of human G-alpha-i1

Released:
DOI: 10.2210/pdb3umr/pdb
PDB entry 3umr coloured by chain, front view.
PDB entry 3umr coloured by chain, side view.
PDB entry 3umr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Johnston CA, Afshar K, Snyder JT, Tall GG, Gonczy P, Siderovski DP, Willard FS

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158954 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand GDP 1 x GDP
Ligand SO4 1 x SO4
Ligand CL 3 x CL
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: I4
Unit cell:
a: 121.952Å b: 121.952Å c: 67.382Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.21
Expression system: Escherichia coli BL21(DE3)

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