› 3vsp

X-ray diffraction
2.4Å resolution

Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28

Released:
DOI: 10.2210/pdb3vsp/pdb
PDB entry 3vsp coloured by chain, front view.
PDB entry 3vsp coloured by chain, side view.
PDB entry 3vsp coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Oyama T, Waku T, Ohashi M, Morikawa K, Miyachi H

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 223-504; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand EK8 1 x EK8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: C2
Unit cell:
a: 93.409Å b: 60.871Å c: 118.598Å
α: 90° β: 102.95° γ: 90°
R-values:
R R work R free
0.222 0.222 0.274
Expression system: Escherichia coli

Quick links