› 3wpf

X-ray diffraction
1.96Å resolution

Crystal structure of mouse TLR9 (unliganded form)

Released:
DOI: 10.2210/pdb3wpf/pdb
PDB entry 3wpf coloured by chain, front view.
PDB entry 3wpf coloured by chain, side view.
PDB entry 3wpf coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.
Ohto U, Shibata T, Tanji H, Ishida H, Krayukhina E, Uchiyama S, Miyake K, Shimizu T
Nature 520 702-5 (2015)
PMID: 25686612

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190163 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 9 Chain: A
Molecule details ›
Chain: A
Length: 803 amino acids
Theoretical weight: 90.17 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9EQU3 (Residues: 26-818; Coverage: 79%)
Gene name: Tlr9
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand SO4 12 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 71.26Å b: 119.28Å c: 130.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.265
Expression system: Drosophila melanogaster

Quick links

Citations

71 review citations

Toll-like Receptors and the Control of Immunity.
Fitzgerald et al. (2020)
70 more

21 mentions without citation

Structural and functional understanding of the toll-like receptors.
Asami et al. (2021)
20 more