Function and Biology Details
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Ankyrin repeat
- Mitogen-activated protein (MAP) kinase, ERK1/2
- Ankyrin repeat-containing domain superfamily
- Serine/threonine-protein kinase, active site
- Mitogen-activated protein (MAP) kinase, conserved site
- Protein kinase, ATP binding site
- Protein kinase domain
- Protein kinase-like domain superfamily
Structure analysis Details
Assemblies composition:
Assembly name:
Mitogen-activated protein kinase 1 (preferred)
PDBe Complex ID:
PDB-CPX-158942 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 1
Molecule details ›
Chain: A
Length: 365 amino acids
Theoretical weight: 42.23 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Protein kinase domain
Structure domains:
Length: 365 amino acids
Theoretical weight: 42.23 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P63086 (Residues: 3-358; Coverage: 99%)
Sequence domains: Protein kinase domain
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
BRUKER AXS MICROSTAR
Spacegroup:
P212121
Expression systems:
- Escherichia coli BL21(DE3)
- Escherichia coli K-12
