Function and Biology Details
Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- Phosphoinositide 3-kinase, accessory (PIK) domain
- C2 phosphatidylinositol 3-kinase-type domain
- Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
- Phosphatidylinositol 3/4-kinase, conserved site
- C2 domain superfamily
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
- Protein kinase-like domain superfamily
5 more domains
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Molecule details ›
Chain: A
Length: 966 amino acids
Theoretical weight: 110.73 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
Sequence domains:
Length: 966 amino acids
Theoretical weight: 110.73 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
- Canonical:
P48736 (Residues: 144-1102; Coverage: 87%)
Sequence domains:
- PI3-kinase family, ras-binding domain
- Phosphoinositide 3-kinase C2
- Phosphoinositide 3-kinase family, accessory domain (PIK domain)
- Phosphatidylinositol 3- and 4-kinase
