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Crystal structure of endonuclease IV from Thermus thermophilus HB8

Source organism: Thermus thermophilus HB8
Biochemical function: metal ion binding
Biological process: DNA damage response
Cellular component: not assigned

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EC 3.1.21.2: Deoxyribonuclease IV

Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products
Systematic name:
-
Alternative Name(s):
  • DNA-adenine-transferase
  • Deoxriboendonuclease
  • Deoxyribonuclease IV (phage T4-induced)
  • E. coli endonuclease IV
  • Endodeoxyribonuclease
  • Endodeoxyribonuclease IV (phage T(4)-induced)
  • Endodeoxyribonuclease IV (phage T4-induced)
  • Endonuclease II
  • Endonuclease IV
  • Escherichia coli endonuclease II
  • Nfo (gene name)
  • Redoxyendonuclease

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01261
Domain description: Xylose isomerase-like TIM barrel
Occurring in:
  1. Xylose isomerase-like TIM barrel domain-containing protein
The deposited structure of PDB entry 3aam contains 1 copy of Pfam domain PF01261 (Xylose isomerase-like TIM barrel) in Xylose isomerase-like TIM barrel domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001719
Domain description: AP endonuclease 2
Occurring in:
  1. Xylose isomerase-like TIM barrel domain-containing protein
IPR018246
Domain description: AP endonuclease 2, zinc binding site
Occurring in:
  1. Xylose isomerase-like TIM barrel domain-containing protein
IPR013022
Domain description: Xylose isomerase-like, TIM barrel domain
Occurring in:
  1. Xylose isomerase-like TIM barrel domain-containing protein
IPR036237
Domain description: Xylose isomerase-like superfamily
Occurring in:
  1. Xylose isomerase-like TIM barrel domain-containing protein

Structure domain

CATH CATH domain
3.20.20.150
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Divalent-metal-dependent TIM barrel enzymes
Occurring in:
  1. Xylose isomerase-like TIM barrel domain-containing protein
The deposited structure of PDB entry 3aam contains 1 copy of CATH domain 3.20.20.150 (TIM Barrel) in Xylose isomerase-like TIM barrel domain-containing protein. Showing 1 copy in chain A.

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