EC 7.1.1.9: Cytochrome-c oxidase
Reaction catalysed:
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Systematic name:
Ferrocytochrome-c:oxygen oxidoreductase
Alternative Name(s):
- Complex IV (mitochondrial electron transport)
- Cytochrome a3
- Cytochrome aa3
- Cytochrome ba(3)
- Cytochrome bb3
- Cytochrome caa(3)
- Cytochrome cbb(3)
- Cytochrome oxidase
- Ferrocytochrome c oxidase
- Indophenol oxidase
- Indophenolase
- NADH cytochrome c oxidase
- Warburg's respiratory enzyme
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR037169
Domain description:
Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily
Occurring in:
Occurring in:
IPR036549
Domain description:
Cytochrome c oxidase subunit 6B/Cytochrome c oxidase assembly factor 6-like superfamily
Occurring in:
Occurring in:
IPR036257
Domain description:
Cytochrome C oxidase subunit II, transmembrane domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
4.10.81.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain M
Homology:
Cytochrome c oxidase, subunit 8
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>4.10.81.10 (Cytochrome C Oxidase; Chain M)</span> in <span class='highlight'>Cytochrome c oxidase subunit 8B, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>M</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 4.10.81.10 (Cytochrome C Oxidase; Chain M) in Cytochrome c oxidase subunit 8B, mitochondrial. Showing 1 copy in chain M.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_13_M_CATH_4.10.81.10_image-200x200.png)
4.10.49.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain L
Homology:
Cytochrome c oxidase subunit VIIc
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>4.10.49.10 (Cytochrome C Oxidase; Chain L)</span> in <span class='highlight'>Cytochrome c oxidase subunit 7C, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>L</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 4.10.49.10 (Cytochrome C Oxidase; Chain L) in Cytochrome c oxidase subunit 7C, mitochondrial. Showing 1 copy in chain L.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_12_L_CATH_4.10.49.10_image-200x200.png)
4.10.51.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain K
Homology:
Cytochrome C Oxidase, chain K
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>4.10.51.10 (Cytochrome C Oxidase; Chain K)</span> in <span class='highlight'>Cytochrome c oxidase subunit 7B, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>K</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 4.10.51.10 (Cytochrome C Oxidase; Chain K) in Cytochrome c oxidase subunit 7B, mitochondrial. Showing 1 copy in chain K.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_11_K_CATH_4.10.51.10_image-200x200.png)
4.10.91.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain J
Homology:
Cytochrome c oxidase, subunit VIIa
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>4.10.91.10 (Cytochrome C Oxidase; Chain J)</span> in <span class='highlight'>Cytochrome c oxidase subunit 7A1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>J</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 4.10.91.10 (Cytochrome C Oxidase; Chain J) in Cytochrome c oxidase subunit 7A1, mitochondrial. Showing 1 copy in chain J.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_10_J_CATH_4.10.91.10_image-200x200.png)
4.10.93.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain I
Homology:
Mitochondrial cytochrome c oxidase subunit VIc/VIIs
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>4.10.93.10 (Cytochrome C Oxidase; Chain I)</span> in <span class='highlight'>Cytochrome c oxidase subunit 6C</span>. Showing 1 copy in chain <span class='highlight'>I</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 4.10.93.10 (Cytochrome C Oxidase; Chain I) in Cytochrome c oxidase subunit 6C. Showing 1 copy in chain I.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_9_I_CATH_4.10.93.10_image-200x200.png)
1.10.10.140
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Arc Repressor Mutant, subunit A
Homology:
Cytochrome c oxidase, subunit VIb
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>1.10.10.140 (Arc Repressor Mutant, subunit A)</span> in <span class='highlight'>Cytochrome c oxidase subunit 6B1</span>. Showing 1 copy in chain <span class='highlight'>H</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 1.10.10.140 (Arc Repressor Mutant, subunit A) in Cytochrome c oxidase subunit 6B1. Showing 1 copy in chain H.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_8_H_CATH_1.10.10.140_image-200x200.png)
4.10.95.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain G
Homology:
Cytochrome c oxidase, subunit VIa
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>4.10.95.10 (Cytochrome C Oxidase; Chain G)</span> in <span class='highlight'>Cytochrome c oxidase subunit 6A2, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>G</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 4.10.95.10 (Cytochrome C Oxidase; Chain G) in Cytochrome c oxidase subunit 6A2, mitochondrial. Showing 1 copy in chain G.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_7_G_CATH_4.10.95.10_image-200x200.png)
2.60.11.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Cytochrome C Oxidase; Chain F
Homology:
Cytochrome c oxidase, subunit Vb
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>2.60.11.10 (Cytochrome C Oxidase; Chain F)</span> in <span class='highlight'>Cytochrome c oxidase subunit 5B, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>F</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 2.60.11.10 (Cytochrome C Oxidase; Chain F) in Cytochrome c oxidase subunit 5B, mitochondrial. Showing 1 copy in chain F.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_6_F_CATH_2.60.11.10_image-200x200.png)
1.25.40.40
Class:
Mainly Alpha
Architecture:
Alpha Horseshoe
Topology:
Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology:
Cytochrome c oxidase, subunit Va/VI
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>1.25.40.40 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat)</span> in <span class='highlight'>Cytochrome c oxidase subunit 5A, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>E</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 1.25.40.40 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Cytochrome c oxidase subunit 5A, mitochondrial. Showing 1 copy in chain E.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_5_E_CATH_1.25.40.40_image-200x200.png)
1.10.442.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Cytochrome C Oxidase; Chain D
Homology:
Cytochrome c oxidase subunit IV
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>1.10.442.10 (Cytochrome C Oxidase; Chain D)</span> in <span class='highlight'>Cytochrome c oxidase subunit 4 isoform 1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>D</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 1.10.442.10 (Cytochrome C Oxidase; Chain D) in Cytochrome c oxidase subunit 4 isoform 1, mitochondrial. Showing 1 copy in chain D.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_4_D_CATH_1.10.442.10_image-200x200.png)
1.20.120.80
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology:
Cytochrome c oxidase, subunit III, four-helix bundle
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>1.20.120.80 (Four Helix Bundle (Hemerythrin (Met), subunit A))</span> in <span class='highlight'>Cytochrome c oxidase subunit 3</span>. Showing 1 copy in chain <span class='highlight'>C</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 1.20.120.80 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Cytochrome c oxidase subunit 3. Showing 1 copy in chain C.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_3_C_CATH_1.20.120.80_image-200x200.png)
1.10.287.70
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helix Hairpins
Homology:
Helix Hairpins
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>1.10.287.70 (Helix Hairpins)</span> in <span class='highlight'>Cytochrome c oxidase subunit 3</span>. Showing 1 copy in chain <span class='highlight'>C</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 1.10.287.70 (Helix Hairpins) in Cytochrome c oxidase subunit 3. Showing 1 copy in chain C.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_3_C_CATH_1.10.287.70_image-200x200.png)
2.60.40.420
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Immunoglobulin-like
Homology:
Cupredoxins - blue copper proteins
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>2.60.40.420 (Immunoglobulin-like)</span> in <span class='highlight'>Cytochrome c oxidase subunit 2</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 2.60.40.420 (Immunoglobulin-like) in Cytochrome c oxidase subunit 2. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_2_B_CATH_2.60.40.420_image-200x200.png)
1.10.287.90
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helix Hairpins
Homology:
Helix Hairpins
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3abl</span> contains 2 copies of CATH domain <span class='highlight'>1.10.287.90 (Helix Hairpins)</span> in <span class='highlight'>Cytochrome c oxidase subunit 2</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 3abl contains 2 copies of CATH domain 1.10.287.90 (Helix Hairpins) in Cytochrome c oxidase subunit 2. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/3abl_2_B_CATH_1.10.287.90_image-200x200.png)