› › Function and Biology

M. luteus B-P 26 heterodimeric hexaprenyl diphosphate synthase in complex with magnesium and FPP analogue

Source organism: Micrococcus luteus
Biochemical function: hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity
Biological process: menaquinone biosynthetic process
Cellular component: not assigned

Quick links

EC 2.5.1.83: Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Reaction catalysed:
(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate
Systematic name:
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)
Alternative Name(s):
  • HexPS
  • Hexaprenyl diphosphate synthase
  • Hexaprenyl pyrophosphate synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00348
Domain description: Polyprenyl synthetase
Occurring in:
  1. Hexaprenyl-diphosphate synthase large subunit ((2E,6E)-farnesyl-diphosphate specific)
The deposited structure of PDB entry 3aqc contains 2 copies of Pfam domain PF00348 (Polyprenyl synthetase) in Hexaprenyl-diphosphate synthase large subunit ((2E,6E)-farnesyl-diphosphate specific). Showing 1 copy in chain D.

PF22538
Domain description: Hexaprenyl diphosphate synthase, small subunit
Occurring in:
  1. Hexaprenyl-diphosphate synthase small subunit ((2E,6E)-farnesyl-diphosphate specific)

InterPro InterPro annotations
IPR033749
Domain description: Polyprenyl synthetase, conserved site
Occurring in:
  1. Hexaprenyl-diphosphate synthase large subunit ((2E,6E)-farnesyl-diphosphate specific)
IPR000092
Domain description: Polyprenyl synthetase
Occurring in:
  1. Hexaprenyl-diphosphate synthase large subunit ((2E,6E)-farnesyl-diphosphate specific)
IPR008949
Domain description: Isoprenoid synthase domain superfamily
Occurring in:
  1. Hexaprenyl-diphosphate synthase large subunit ((2E,6E)-farnesyl-diphosphate specific)

Structure domains

CATH CATH domains
1.10.600.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Farnesyl Diphosphate Synthase
Homology: Farnesyl Diphosphate Synthase
Occurring in:
  1. Hexaprenyl-diphosphate synthase large subunit ((2E,6E)-farnesyl-diphosphate specific)
The deposited structure of PDB entry 3aqc contains 2 copies of CATH domain 1.10.600.10 (Farnesyl Diphosphate Synthase) in Hexaprenyl-diphosphate synthase large subunit ((2E,6E)-farnesyl-diphosphate specific). Showing 1 copy in chain D.
1.20.120.1450
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Occurring in:
  1. Hexaprenyl-diphosphate synthase small subunit ((2E,6E)-farnesyl-diphosphate specific)
The deposited structure of PDB entry 3aqc contains 2 copies of CATH domain 1.20.120.1450 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Hexaprenyl-diphosphate synthase small subunit ((2E,6E)-farnesyl-diphosphate specific). Showing 1 copy in chain A.

Quick links