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Crystal structure of Streptomyces tyrosinase in a complex with caddie H82Q mutant soaked in a Cu(II)-containing solution for 80 hr

X-ray diffraction
1.25Å resolution
PDB entry 3awx coloured by chain, front view.
PDB entry 3awx coloured by chain, side view.
PDB entry 3awx coloured by chain, top view.
Source organism: Streptomyces castaneoglobisporus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: MelC and Tyrosinase copper-binding domain-containing protein
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Multimeric state: hetero dimer
Accessible surface area: 13690.33 Å2
Buried surface area: 3637.52 Å2
Dissociation area: 1,067.11 Å2
Dissociation energy (ΔGdiss): 13.9 kcal/mol
Dissociation entropy (TΔSdiss): 11.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-182976

Macromolecules

Tyrosinase copper-binding domain-containing protein
Chain: A
Length: 281 amino acids
Theoretical weight: 32.09 KDa
Source organism: Streptomyces castaneoglobisporus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q83WS2 (Residues: 1-273; Coverage: 100%)
Pfam: Common central domain of tyrosinase
InterPro:
CATH: Di-copper center containing domain from catechol oxidase
Tyrosinase copper-binding domain-containing protein in PDB entry 3awx, assembly 1, front view.
Tyrosinase copper-binding domain-containing protein in PDB entry 3awx, assembly 1, side view.
Tyrosinase copper-binding domain-containing protein in PDB entry 3awx, assembly 1, top view.
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MelC
Chain: B
Length: 134 amino acids
Theoretical weight: 14.08 KDa
Source organism: Streptomyces castaneoglobisporus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q83WS1 (Residues: 1-126; Coverage: 100%)
Pfam: Tyrosinase co-factor MelC1
InterPro:
CATH: protein ne1242 domain like
MelC in PDB entry 3awx, assembly 1, front view.
MelC in PDB entry 3awx, assembly 1, side view.
MelC in PDB entry 3awx, assembly 1, top view.
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