› 3b7a

X-ray diffraction
1.9Å resolution

Complex of S52A Substituted Droposphila LUSH protein with Ethanol

Released:
DOI: 10.2210/pdb3b7a/pdb
PDB entry 3b7a coloured by chain, front view.
PDB entry 3b7a coloured by chain, side view.
PDB entry 3b7a coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
The role of multiple hydrogen-bonding groups in specific alcohol binding sites in proteins: insights from structural studies of LUSH.
Thode AB, Kruse SW, Nix JC, Jones DN
J Mol Biol 376 1360-76 (2008)
PMID: 18234222

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126416 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
General odorant-binding protein lush Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 14.2 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: O02372 (Residues: 30-153; Coverage: 100%)
Gene names: CG8807, Obp76a, Obp76c, lush
Sequence domains: PBP/GOBP family
Structure domains: Pheromone/general odorant binding protein domain

Ligands and Environments

2 bound ligands:
Ligand EOH 1 x EOH
Ligand ACT 5 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P43
Unit cell:
a: 46.873Å b: 46.873Å c: 111.206Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.198 0.236
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Ethanol's molecular targets.
Harris et al. (2008)
4 more

3 mentions without citation

Ligands for pheromone-sensing neurons are not conformationally activated odorant binding proteins.
Gomez-Diaz et al. (2013)
2 more