EC 4.2.1.11: Phosphopyruvate hydratase
Reaction catalysed:
2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O
Systematic name:
2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
Alternative Name(s):
- 14-3-2-protein
- 2-phospho-D-glycerate hydro-lyase
- 2-phosphoglycerate dehydratase
- 2-phosphoglycerate enolase
- 2-phosphoglyceric dehydratase
- Enolase
- Gamma-enolase
- Nervous-system specific enolase
- Phosphoenolpyruvate hydratase
GO terms
Biochemical function:
- GTPase binding
- metal ion binding
- cadherin binding
- protein homodimerization activity
- lyase activity
- protein binding
- phosphopyruvate hydratase activity
- RNA binding
- transcription corepressor activity
- DNA binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- transcription corepressor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- magnesium ion binding
Biological process:
- positive regulation of ATP biosynthetic process
- negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
- canonical glycolysis
- positive regulation of muscle contraction
- negative regulation of DNA-templated transcription
- negative regulation of cell growth
- positive regulation of plasminogen activation
- response to virus
- glycolytic process
- gluconeogenesis
- negative regulation of transcription by RNA polymerase II
Protein families (Pfam)
InterPro annotations
CATH domains
