› 3b9i

X-ray diffraction
2.49Å resolution

Crystal Structure of mouse GITRL at 2.5 A.

Released:
DOI: 10.2210/pdb3b9i/pdb
PDB entry 3b9i coloured by chain, front view.
PDB entry 3b9i coloured by chain, side view.
PDB entry 3b9i coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Chattopadhyay K, Ramagopal UA, Brenowitz M, Nathenson SG, Almo SC
Proc Natl Acad Sci U S A 105 635-40 (2008)
PMID: 18182486

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182023 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 18 Chains: A, B
Molecule details ›
Chains: A, B
Length: 132 amino acids
Theoretical weight: 15.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7TS55 (Residues: 46-173; Coverage: 74%)
Gene names: Gitrl, Tnfsf18
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 52.791Å b: 70.024Å c: 71.654Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.248
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Structural principles of tumor necrosis factor superfamily signaling.
Vanamee et al. (2018)
12 more

1 mention without citation

Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Chattopadhyay et al. (2008)