› 3b9u

X-ray diffraction
1.55Å resolution

Crystal structure of L26N/D28N/H93G mutant of Human acidic fibroblast growth factor

Released:
DOI: 10.2210/pdb3b9u/pdb
PDB entry 3b9u coloured by chain, front view.
PDB entry 3b9u coloured by chain, side view.
PDB entry 3b9u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
Lee J, Dubey VK, Longo LM, Blaber M
J Mol Biol 377 1251-64 (2008)
PMID: 18308335

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 33.389Å b: 44.19Å c: 47.957Å
α: 90° β: 100.45° γ: 90°
R-values:
R R work R free
0.191 0.191 0.2
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Protein design at the interface of the pre-biotic and biotic worlds.
Longo et al. (2012)
2 more

1 mention without citation

Comprehensive analysis of the dynamic structure of nuclear localization signals.
Yamagishi et al. (2015)