› › Function and Biology

Crystal structure of mouse selenocysteine synthase, sodium phosphate soak

Source organism: Mus musculus
Biochemical function: O-phosphoseryl-tRNA(Sec) selenium transferase activity
Biological process: conversion of seryl-tRNAsec to selenocys-tRNAsec
Cellular component: not assigned

Quick links

EC 2.9.1.2: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase

Reaction catalysed:
O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H(2)O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate
Systematic name:
Selenophosphate:O-phospho-L-seryl-tRNA(Sec) selenium transferase
Alternative Name(s):
  • MMPSepSecS
  • O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase
  • O-phosphoseryl-tRNA(Sec) selenium transferase
  • O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase
  • SLA/LP
  • SepSecS

GO terms

Sequence family

Pfam Protein family (Pfam)
PF05889
Domain description: O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS
Occurring in:
  1. O-phosphoseryl-tRNA(Sec) selenium transferase
The deposited structure of PDB entry 3bcb contains 1 copy of Pfam domain PF05889 (O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS) in O-phosphoseryl-tRNA(Sec) selenium transferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019872
Domain description: O-phosphoseryl-tRNA(Sec) selenium transferase
Occurring in:
  1. O-phosphoseryl-tRNA(Sec) selenium transferase
IPR008829
Domain description: SepSecS/SepCysS family
Occurring in:
  1. O-phosphoseryl-tRNA(Sec) selenium transferase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. O-phosphoseryl-tRNA(Sec) selenium transferase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. O-phosphoseryl-tRNA(Sec) selenium transferase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. O-phosphoseryl-tRNA(Sec) selenium transferase
The deposited structure of PDB entry 3bcb contains 1 copy of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in O-phosphoseryl-tRNA(Sec) selenium transferase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. O-phosphoseryl-tRNA(Sec) selenium transferase
The deposited structure of PDB entry 3bcb contains 1 copy of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in O-phosphoseryl-tRNA(Sec) selenium transferase. Showing 1 copy in chain A.
1.10.10.2160
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Arc Repressor Mutant, subunit A
Occurring in:
  1. O-phosphoseryl-tRNA(Sec) selenium transferase
The deposited structure of PDB entry 3bcb contains 1 copy of CATH domain 1.10.10.2160 (Arc Repressor Mutant, subunit A) in O-phosphoseryl-tRNA(Sec) selenium transferase. Showing 1 copy in chain A.
SCOP SCOP annotation
159704
Class: Alpha and beta proteins (a/b)
Fold: PLP-dependent transferase-like
Superfamily: PLP-dependent transferases
Occurring in:
  1. O-phosphoseryl-tRNA(Sec) selenium transferase
The deposited structure of PDB entry 3bcb contains 1 copy of SCOP domain 159704 (SepSecS-like) in O-phosphoseryl-tRNA(Sec) selenium transferase. Showing 1 copy in chain A.

Quick links