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Crystal Structure of the Class A beta-lactamase SED-G238C mutant from Citrobacter sedlakii

Source organism: Citrobacter sedlakii
Biochemical function: hydrolase activity
Biological process: response to antibiotic
Cellular component: not assigned

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EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

GO terms

Sequence families

Pfam Protein families (Pfam)
PF13354
Domain description: Beta-lactamase enzyme family
Occurring in:
  1. Beta-lactamase
The deposited structure of PDB entry 3bfd contains 4 copies of Pfam domain PF13354 (Beta-lactamase enzyme family) in Beta-lactamase. Showing 1 copy in chain A.

PF00905
Domain description: Penicillin binding protein transpeptidase domain
Occurring in:
  1. Beta-lactamase
The deposited structure of PDB entry 3bfd contains 4 copies of Pfam domain PF00905 (Penicillin binding protein transpeptidase domain) in Beta-lactamase. Showing 1 copy in chain A.

PF00144
Domain description: Beta-lactamase
Occurring in:
  1. Beta-lactamase
The deposited structure of PDB entry 3bfd contains 4 copies of Pfam domain PF00144 (Beta-lactamase) in Beta-lactamase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000871
Domain description: Beta-lactamase, class-A
Occurring in:
  1. Beta-lactamase
IPR012338
Domain description: Beta-lactamase/transpeptidase-like
Occurring in:
  1. Beta-lactamase
IPR023650
Domain description: Beta-lactamase, class-A active site
Occurring in:
  1. Beta-lactamase
IPR045155
Domain description: Beta-lactamase class A, catalytic domain
Occurring in:
  1. Beta-lactamase

Structure domain

CATH CATH domain
3.40.710.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Beta-lactamase
Homology: DD-peptidase/beta-lactamase superfamily
Occurring in:
  1. Beta-lactamase
The deposited structure of PDB entry 3bfd contains 4 copies of CATH domain 3.40.710.10 (Beta-lactamase) in Beta-lactamase. Showing 1 copy in chain A.

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