› 3bix

X-ray diffraction
1.8Å resolution

Crystal structure of the extracellular esterase domain of Neuroligin-1

Released:
DOI: 10.2210/pdb3bix/pdb
PDB entry 3bix coloured by chain, front view.
PDB entry 3bix coloured by chain, side view.
PDB entry 3bix coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions.
Araç D, Boucard AA, Ozkan E, Strop P, Newell E, Südhof TC, Brunger AT
Neuron 56 992-1003 (2007)
PMID: 18093522

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178965 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuroligin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 574 amino acids
Theoretical weight: 64.23 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q62765 (Residues: 46-638; Coverage: 71%)
  • Best match: Q62765-2 (Residues: 46-277, 278-609)
Gene name: Nlgn1
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

3 bound ligands:
Ligand NAG 8 x NAG
Ligand NI 2 x NI
Ligand EDO 14 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P32
Unit cell:
a: 173.744Å b: 173.744Å c: 108.045Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.185 0.205
Expression system: Trichoplusia ni

Quick links

Citations

26 review citations

Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC. (2008)
25 more

6 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
5 more