Function and Biology Details
Reaction catalysed:
Broad endopeptidase specificity.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-541469 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Calpain-2 catalytic subunit
Molecule details ›
Chain: A
Length: 714 amino acids
Theoretical weight: 81.58 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 714 amino acids
Theoretical weight: 81.58 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q07009 (Residues: 1-700; Coverage: 100%)
Sequence domains:
Structure domains:
Calpain small subunit 1
Molecule details ›
Chain: B
Length: 184 amino acids
Theoretical weight: 21.3 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains: EF-hand domain pair
Structure domains: EF-hand
Length: 184 amino acids
Theoretical weight: 21.3 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical: Q64537 (Residues: 88-270; Coverage: 68%)
Sequence domains: EF-hand domain pair
Structure domains: EF-hand
Calpastatin
Molecule details ›
Chain: C
Length: 95 amino acids
Theoretical weight: 10.77 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains: Calpain inhibitor
Length: 95 amino acids
Theoretical weight: 10.77 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical: P27321 (Residues: 571-664; Coverage: 13%)
Sequence domains: Calpain inhibitor
