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Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with an acetate ion bound at the active site

Source organism: Clostridium botulinum
Biochemical function: zinc ion binding
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.24.69: Bontoxilysin

Reaction catalysed:
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates.
Systematic name:
-
Alternative Name(s):
  • BoNT
  • Botulinum neurotoxin

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01742
Domain description: Clostridial neurotoxin zinc protease
Occurring in:
  1. Botulinum neurotoxin A light chain
The deposited structure of PDB entry 3bwi contains 1 copy of Pfam domain PF01742 (Clostridial neurotoxin zinc protease) in Botulinum neurotoxin A light chain. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR000395
Domain description: Botulinum/Tetanus toxin, catalytic chain
Occurring in:
  1. Botulinum neurotoxin A light chain

Structure domain

CATH CATH domain
3.90.1240.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Zincin-like
Homology: Metalloproteases ("zincins"), catalytic domain like
Occurring in:
  1. Botulinum neurotoxin A light chain
The deposited structure of PDB entry 3bwi contains 1 copy of CATH domain 3.90.1240.10 (Zincin-like) in Botulinum neurotoxin A light chain. Showing 1 copy in chain A.

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