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Small molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling

Source organism: Arabidopsis thaliana
Biochemical function: protein binding
Biological process: protein ubiquitination
Cellular component: SCF ubiquitin ligase complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF18791
Domain description: Transport inhibitor response 1 protein domain
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1
The deposited structure of PDB entry 3c6p contains 1 copy of Pfam domain PF18791 (Transport inhibitor response 1 protein domain) in Protein TRANSPORT INHIBITOR RESPONSE 1. Showing 1 copy in chain B.

PF00646
Domain description: F-box domain
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1

PF01466
Domain description: Skp1 family, dimerisation domain
Occurring in:
  1. SKP1-like protein 1A
The deposited structure of PDB entry 3c6p contains 1 copy of Pfam domain PF01466 (Skp1 family, dimerisation domain) in SKP1-like protein 1A. Showing 1 copy in chain A.

PF03931
Domain description: Skp1 family, tetramerisation domain
Occurring in:
  1. SKP1-like protein 1A
The deposited structure of PDB entry 3c6p contains 1 copy of Pfam domain PF03931 (Skp1 family, tetramerisation domain) in SKP1-like protein 1A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006553
Domain description: Leucine-rich repeat, cysteine-containing subtype
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1
IPR016897
Domain description: S-phase kinase-associated protein 1
Occurring in:
  1. SKP1-like protein 1A
IPR011333
Domain description: SKP1/BTB/POZ domain superfamily
Occurring in:
  1. SKP1-like protein 1A
IPR041101
Domain description: Transport inhibitor response 1 domain
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1
IPR032675
Domain description: Leucine-rich repeat domain superfamily
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1
IPR001810
Domain description: F-box domain
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1
IPR041567
Domain description: COI1, F-box
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1
IPR036047
Domain description: F-box-like domain superfamily
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1
IPR016072
Domain description: SKP1 component, dimerisation
Occurring in:
  1. SKP1-like protein 1A
IPR036296
Domain description: SKP1-like, dimerisation domain superfamily
Occurring in:
  1. SKP1-like protein 1A
IPR016073
Domain description: SKP1 component, POZ domain
Occurring in:
  1. SKP1-like protein 1A
IPR001232
Domain description: S-phase kinase-associated protein 1-like
Occurring in:
  1. SKP1-like protein 1A

Structure domains

CATH CATH domains
3.80.10.10
Class: Alpha Beta
Architecture: Alpha-Beta Horseshoe
Topology: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homology: Ribonuclease Inhibitor
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1
The deposited structure of PDB entry 3c6p contains 1 copy of CATH domain 3.80.10.10 (Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)) in Protein TRANSPORT INHIBITOR RESPONSE 1. Showing 1 copy in chain B.
1.20.1280.50
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Monooxygenase
Homology: Monooxygenase
Occurring in:
  1. Protein TRANSPORT INHIBITOR RESPONSE 1
The deposited structure of PDB entry 3c6p contains 1 copy of CATH domain 1.20.1280.50 (Monooxygenase) in Protein TRANSPORT INHIBITOR RESPONSE 1. Showing 1 copy in chain B.
3.30.710.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Potassium Channel Kv1.1; Chain A
Homology: Potassium Channel Kv1.1; Chain A
Occurring in:
  1. SKP1-like protein 1A
The deposited structure of PDB entry 3c6p contains 1 copy of CATH domain 3.30.710.10 (Potassium Channel Kv1.1; Chain A) in SKP1-like protein 1A. Showing 1 copy in chain A.

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