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Crystal structure of leukotriene a4 hydrolase in complex with 2-amino-N-[4-(phenylmethoxy)phenyl]-acetamide

Source organism: Homo sapiens
Biochemical function: metalloaminopeptidase activity
Biological process: type I pneumocyte differentiation
Cellular component: ficolin-1-rich granule lumen

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EC 3.4.11.4: Tripeptide aminopeptidase

Reaction catalysed:
Release of the N-terminal residue from a tripeptide.
Alternative Name(s):
  • Alanine-phenylalanine-proline arylamidase
  • Aminoexotripeptidase
  • Aminotripeptidase
  • Imidoendopeptidase
  • Lymphopeptidase
  • Peptidase B
  • Peptidase T
  • Tripeptidase

EC 3.3.2.6: Leukotriene-A(4) hydrolase

Reaction catalysed:
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
Systematic name:
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase
Alternative Name(s):
  • LTA(4) hydrolase
  • LTA-4 hydrolase
  • LTA4H
  • Leukotriene A(4) hydrolase
  • Leukotriene-A4 hydrolase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF09127
Domain description: Leukotriene A4 hydrolase, C-terminal
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of Pfam domain PF09127 (Leukotriene A4 hydrolase, C-terminal) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.

PF01433
Domain description: Peptidase family M1 domain
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of Pfam domain PF01433 (Peptidase family M1 domain) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.

PF17900
Domain description: Peptidase M1 N-terminal domain
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of Pfam domain PF17900 (Peptidase M1 N-terminal domain) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001930
Domain description: Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Occurring in:
  1. Leukotriene A-4 hydrolase
IPR015211
Domain description: Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal
Occurring in:
  1. Leukotriene A-4 hydrolase
IPR042097
Domain description: Aminopeptidase N-like , N-terminal domain superfamliy
Occurring in:
  1. Leukotriene A-4 hydrolase
IPR034015
Domain description: Aminopeptidase, leukotriene A4 hydrolase-like
Occurring in:
  1. Leukotriene A-4 hydrolase
IPR038502
Domain description: Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily
Occurring in:
  1. Leukotriene A-4 hydrolase
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Leukotriene A-4 hydrolase
IPR027268
Domain description: Peptidase M4/M1, CTD superfamily
Occurring in:
  1. Leukotriene A-4 hydrolase
IPR014782
Domain description: Peptidase M1, membrane alanine aminopeptidase
Occurring in:
  1. Leukotriene A-4 hydrolase
IPR045357
Domain description: Aminopeptidase N-like , N-terminal domain
Occurring in:
  1. Leukotriene A-4 hydrolase
IPR012777
Domain description: Leukotriene A4 hydrolase/leucine aminopeptidase
Occurring in:
  1. Leukotriene A-4 hydrolase

Structure domains

CATH CATH domains
1.25.40.320
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of CATH domain 1.25.40.320 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.
1.10.390.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Neutral Protease; domain 2
Homology: Neutral Protease Domain 2
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of CATH domain 1.10.390.10 (Neutral Protease; domain 2) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.
3.30.2010.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Zincin-like
Homology: Zincin-like
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of CATH domain 3.30.2010.30 (Zincin-like) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.
2.60.40.1730
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: tricorn interacting facor f3 domain
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of CATH domain 2.60.40.1730 (Immunoglobulin-like) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.
SCOP SCOP annotations
63608
Class: All alpha proteins
Fold: alpha-alpha superhelix
Superfamily: ARM repeat
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of SCOP domain 63608 (Leukotriene A4 hydrolase C-terminal domain) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.
64338
Class: Alpha and beta proteins (a+b)
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of SCOP domain 64338 (Leukotriene A4 hydrolase catalytic domain) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.
63738
Class: All beta proteins
Fold: Leukotriene A4 hydrolase N-terminal domain
Superfamily: Leukotriene A4 hydrolase N-terminal domain
Occurring in:
  1. Leukotriene A-4 hydrolase
The deposited structure of PDB entry 3cho contains 1 copy of SCOP domain 63738 (Leukotriene A4 hydrolase N-terminal domain) in Leukotriene A-4 hydrolase. Showing 1 copy in chain A.

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