Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- C-type lectin-like
- Immunoglobulin C1-set
- MHC class I alpha chain, alpha1 alpha2 domains
- Natural killer cell receptor-like, C-type lectin-like domain
- C-type lectin fold
- C-type lectin-like/link domain superfamily
- Beta-2-Microglobulin
- Immunoglobulin/major histocompatibility complex, conserved site
7 more domains
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
CD94-NKG2A natural killer receptor complex (preferred)
PDBe Complex ID:
PDB-CPX-146744 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Soluble HLA class I histocompatibility antigen, alpha chain E
Molecule details ›
Chains: A, D
Length: 273 amino acids
Theoretical weight: 31.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 273 amino acids
Theoretical weight: 31.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P13747 (Residues: 23-295; Coverage: 81%)
Sequence domains:
Beta-2-microglobulin
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Immunoglobulin C1-set domain
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Sequence domains: Immunoglobulin C1-set domain
Soluble HLA class I histocompatibility antigen, alpha chain G
Natural killer cells antigen CD94
NKG2-A/NKG2-B type II integral membrane protein
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
ALS BEAMLINE 8.2.2
Spacegroup:
I4132
Expression systems:
- Escherichia coli
- Not provided
