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REFINED CRYSTAL STRUCTURE OF TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE AT 1.75 ANGSTROMS RESOLUTION

Source organism: Escherichia coli
Biochemical function: acyltransferase activity
Biological process: response to antibiotic
Cellular component: not assigned

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EC 2.3.1.28: Chloramphenicol O-acetyltransferase

Reaction catalysed:
Acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate
Systematic name:
Acetyl-CoA:chloramphenicol 3-O-acetyltransferase
Alternative Name(s):
  • CAT I
  • CAT II
  • CAT III
  • Chloramphenicol acetylase
  • Chloramphenicol acetyltransferase
  • Chloramphenicol transacetylase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00302
Domain description: Chloramphenicol acetyltransferase
Occurring in:
  1. Chloramphenicol acetyltransferase 3
The deposited structure of PDB entry 3cla contains 1 copy of Pfam domain PF00302 (Chloramphenicol acetyltransferase) in Chloramphenicol acetyltransferase 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001707
Domain description: Chloramphenicol acetyltransferase
Occurring in:
  1. Chloramphenicol acetyltransferase 3
IPR018372
Domain description: Chloramphenicol acetyltransferase, active site
Occurring in:
  1. Chloramphenicol acetyltransferase 3
IPR023213
Domain description: Chloramphenicol acetyltransferase-like domain superfamily
Occurring in:
  1. Chloramphenicol acetyltransferase 3

Structure domain

CATH CATH domain
3.30.559.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Chloramphenicol Acetyltransferase
Homology: Chloramphenicol acetyltransferase-like domain
Occurring in:
  1. Chloramphenicol acetyltransferase 3
The deposited structure of PDB entry 3cla contains 1 copy of CATH domain 3.30.559.10 (Chloramphenicol Acetyltransferase) in Chloramphenicol acetyltransferase 3. Showing 1 copy in chain A.
SCOP SCOP annotation
52778
Class: Alpha and beta proteins (a/b)
Fold: CoA-dependent acyltransferases
Superfamily: CoA-dependent acyltransferases
Occurring in:
  1. Chloramphenicol acetyltransferase 3
The deposited structure of PDB entry 3cla contains 1 copy of SCOP domain 52778 (CAT-like) in Chloramphenicol acetyltransferase 3. Showing 1 copy in chain A.

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