EC 2.7.11.24: Mitogen-activated protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (MAPKK-activated)
Alternative Name(s):
- C-Jun N-terminal kinase
- Dp38
- ERK
- ERK1
- ERK2
- Extracellular signal-regulated kinase
- JNK
- JNK3-alpha-1
- LeMPK3
- MAP kinase
- MAP-2 kinase
- MAPK
- MBP kinase I
- MBP kinase II
- Microtubule-associated protein 2 kinase
- Microtubule-associated protein kinase
- Myelin basic protein kinase
- P38-2
- P38-delta
- P42 mitogen-activated protein kinase
- P42(mapk)
- P44mpk
- PMK-1
- PMK-2
- PMK-3
- Pp42
- Pp44(mapk)
- SAPK
- STK26
- Stress-activated protein kinase
GO terms
Biochemical function:
Biological process:
- cellular response to sodium arsenite
- cellular response to anisomycin
- cellular response to sorbitol
- cellular response to interleukin-1
- cellular response to hydrogen peroxide
- stress-activated MAPK cascade
- positive regulation of inflammatory response
- intracellular signal transduction
- cellular response to UV
- cellular response to stress
- positive regulation of interleukin-6 production
- peptidyl-serine phosphorylation
- JNK cascade
- response to osmotic stress
- protein phosphorylation
- MAPK cascade
Cellular component:
Sequence family
Protein family (Pfam)
InterPro annotations
Structure domains
CATH domains
1.10.510.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Transferase(Phosphotransferase); domain 1
Homology:
Transferase(Phosphotransferase) domain 1
Occurring in:
