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Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn

Source organism: Homo sapiens
Biochemical function: S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
Biological process: quinone metabolic process
Cellular component: cytosol

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EC 1.1.1.105: All-trans-retinol dehydrogenase (NAD(+))

Reaction catalysed:
All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) = all-trans-retinal-[cellular-retinol-binding-protein] + NADH
Systematic name:
All-trans retinol:NAD(+) oxidoreductase
Alternative Name(s):
  • All-trans retinol dehydrogenase
  • Epidermal retinol dehydrogenase 2
  • MDR
  • Microsomal retinol dehydrogenase
  • RDH16 (gene name)
  • Retinal reductase
  • Retinene reductase
  • Retinol (vitamin A(1)) dehydrogenase
  • Retinol dehydrogenase
  • SDR16C5 (gene name)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00107
Domain description: Zinc-binding dehydrogenase
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4
The deposited structure of PDB entry 3cos contains 4 copies of Pfam domain PF00107 (Zinc-binding dehydrogenase) in All-trans-retinol dehydrogenase [NAD(+)] ADH4. Showing 1 copy in chain D.

PF08240
Domain description: Alcohol dehydrogenase GroES-like domain
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4
The deposited structure of PDB entry 3cos contains 4 copies of Pfam domain PF08240 (Alcohol dehydrogenase GroES-like domain) in All-trans-retinol dehydrogenase [NAD(+)] ADH4. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR011032
Domain description: GroES-like superfamily
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4
IPR013149
Domain description: Alcohol dehydrogenase-like, C-terminal
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4
IPR002328
Domain description: Alcohol dehydrogenase, zinc-type, conserved site
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4
IPR013154
Domain description: Alcohol dehydrogenase-like, N-terminal
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4
IPR020843
Domain description: Polyketide synthase, enoylreductase domain
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4

Structure domains

CATH CATH domains
3.90.180.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Quinone Oxidoreductase; Chain A, domain 1
Homology: Medium-chain alcohol dehydrogenases, catalytic domain
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4
The deposited structure of PDB entry 3cos contains 4 copies of CATH domain 3.90.180.10 (Quinone Oxidoreductase; Chain A, domain 1) in All-trans-retinol dehydrogenase [NAD(+)] ADH4. Showing 1 copy in chain D.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. All-trans-retinol dehydrogenase [NAD(+)] ADH4
The deposited structure of PDB entry 3cos contains 4 copies of CATH domain 3.40.50.720 (Rossmann fold) in All-trans-retinol dehydrogenase [NAD(+)] ADH4. Showing 1 copy in chain D.

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