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4-Chlorobenzoyl-CoA Ligase/Synthetase in the Thioester-forming Conformation, bound to 4-chlorophenacyl-CoA

Source organism: Alcaligenes sp. AL3007
Biochemical function: metal ion binding
Biological process: fatty acid metabolic process
Cellular component: membrane

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EC 6.2.1.33: 4-chlorobenzoate--CoA ligase

Reaction catalysed:
4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate
Systematic name:
4-chlorobenzoate:CoA ligase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF13193
Domain description: AMP-binding enzyme C-terminal domain
Occurring in:
  1. 4-chlorobenzoyl CoA ligase
The deposited structure of PDB entry 3cw9 contains 2 copies of Pfam domain PF13193 (AMP-binding enzyme C-terminal domain) in 4-chlorobenzoyl CoA ligase. Showing 1 copy in chain A.

PF00501
Domain description: AMP-binding enzyme
Occurring in:
  1. 4-chlorobenzoyl CoA ligase
The deposited structure of PDB entry 3cw9 contains 2 copies of Pfam domain PF00501 (AMP-binding enzyme) in 4-chlorobenzoyl CoA ligase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR025110
Domain description: AMP-binding enzyme, C-terminal domain
Occurring in:
  1. 4-chlorobenzoyl CoA ligase
IPR045851
Domain description: AMP-binding enzyme, C-terminal domain superfamily
Occurring in:
  1. 4-chlorobenzoyl CoA ligase
IPR020845
Domain description: AMP-binding, conserved site
Occurring in:
  1. 4-chlorobenzoyl CoA ligase
IPR000873
Domain description: AMP-dependent synthetase/ligase domain
Occurring in:
  1. 4-chlorobenzoyl CoA ligase

Structure domains

CATH CATH domains
3.40.50.980
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. 4-chlorobenzoyl CoA ligase
The deposited structure of PDB entry 3cw9 contains 4 copies of CATH domain 3.40.50.980 (Rossmann fold) in 4-chlorobenzoyl CoA ligase. Showing 2 copies in chain A.
3.30.300.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GMP Synthetase; Chain A, domain 3
Homology: GMP Synthetase; Chain A, domain 3
Occurring in:
  1. 4-chlorobenzoyl CoA ligase
The deposited structure of PDB entry 3cw9 contains 2 copies of CATH domain 3.30.300.30 (GMP Synthetase; Chain A, domain 3) in 4-chlorobenzoyl CoA ligase. Showing 1 copy in chain A.
2.30.38.10
Class: Mainly Beta
Architecture: Roll
Topology: Luciferase; domain 3
Homology: Luciferase; Domain 3
Occurring in:
  1. 4-chlorobenzoyl CoA ligase
The deposited structure of PDB entry 3cw9 contains 2 copies of CATH domain 2.30.38.10 (Luciferase; domain 3) in 4-chlorobenzoyl CoA ligase. Showing 1 copy in chain A.
SCOP SCOP annotation
56802
Class: Multi-domain proteins (alpha and beta)
Fold: Acetyl-CoA synthetase-like
Superfamily: Acetyl-CoA synthetase-like
Occurring in:
  1. 4-chlorobenzoyl CoA ligase
The deposited structure of PDB entry 3cw9 contains 2 copies of SCOP domain 56802 (Acetyl-CoA synthetase-like) in 4-chlorobenzoyl CoA ligase. Showing 1 copy in chain A.

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