Function and Biology

Structural recognition and functional activation of FcrR by innate pentraxins

Source organism: Homo sapiens
Biochemical function: unfolded protein binding
Biological process: negative regulation of glycoprotein metabolic process
Cellular component: blood microparticle

Sequence families

Pfam Protein families (Pfam)
PF00354
Domain description: Pentaxin family
Occurring in:
  1. Serum amyloid P-component
The deposited structure of PDB entry 3d5o contains 5 copies of Pfam domain PF00354 (Pentaxin family) in Serum amyloid P-component. Showing 1 copy in chain A.

PF13895
Domain description: Immunoglobulin domain
Occurring in:
  1. Low affinity immunoglobulin gamma Fc region receptor II-a
The deposited structure of PDB entry 3d5o contains 2 copies of Pfam domain PF13895 (Immunoglobulin domain) in Low affinity immunoglobulin gamma Fc region receptor II-a. Showing 2 copies in chain F.

InterPro InterPro annotations
IPR001759
Domain description: Pentraxin-related
Occurring in:
  1. Serum amyloid P-component
IPR030476
Domain description: Pentaxin, conserved site
Occurring in:
  1. Serum amyloid P-component
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Serum amyloid P-component
IPR003598
Domain description: Immunoglobulin subtype 2
Occurring in:
  1. Low affinity immunoglobulin gamma Fc region receptor II-a
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Low affinity immunoglobulin gamma Fc region receptor II-a
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Low affinity immunoglobulin gamma Fc region receptor II-a
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Low affinity immunoglobulin gamma Fc region receptor II-a
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Low affinity immunoglobulin gamma Fc region receptor II-a

Structure domains

CATH CATH domains
2.60.120.200
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Serum amyloid P-component
The deposited structure of PDB entry 3d5o contains 5 copies of CATH domain 2.60.120.200 (Jelly Rolls) in Serum amyloid P-component. Showing 1 copy in chain A.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Low affinity immunoglobulin gamma Fc region receptor II-a
The deposited structure of PDB entry 3d5o contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Low affinity immunoglobulin gamma Fc region receptor II-a. Showing 2 copies in chain F.