Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132630 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase CSK
Molecule details ›
Chains: A, C
Length: 263 amino acids
Theoretical weight: 29.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Length: 263 amino acids
Theoretical weight: 29.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P41240 (Residues: 188-450; Coverage: 58%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Proto-oncogene tyrosine-protein kinase Src
Molecule details ›
Chains: B, D
Length: 277 amino acids
Theoretical weight: 31.8 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Length: 277 amino acids
Theoretical weight: 31.8 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
- Canonical: P00523 (Residues: 260-523; Coverage: 50%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.2.1
Spacegroup:
P31
Expression system: Escherichia coli
