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Crystal structure of GlmU from Mycobacterium tuberculosis in complex with uridine-diphosphate-N-acetylglucosamine

Source organism: Mycobacterium tuberculosis
Biochemical function: uridylyltransferase activity
Biological process: cell wall organization
Cellular component: membrane

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EC 2.7.7.23: UDP-N-acetylglucosamine diphosphorylase

Reaction catalysed:
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine
Systematic name:
UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase
Alternative Name(s):
  • Acetylglucosamine 1-phosphate uridylyltransferase
  • GlmU uridylyltransferase
  • N-acetylglucosamine-1-phosphate uridyltransferase
  • UDP-GlcNAc pyrophosphorylase
  • UDP-N-acetylglucosamine pyrophosphorylase
  • UDP-acetylglucosamine pyrophosphorylase
  • UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase
  • Uridine diphosphate-N-acetylglucosamine pyrophosphorylase
  • Uridine diphosphoacetylglucosamine phosphorylase
  • Uridine diphosphoacetylglucosamine pyrophosphorylase

EC 2.3.1.157: Glucosamine-1-phosphate N-acetyltransferase

Reaction catalysed:
Acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
Systematic name:
Acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00132
Domain description: Bacterial transferase hexapeptide (six repeats)
Occurring in:
  1. Bifunctional protein GlmU

PF12804
Domain description: MobA-like NTP transferase domain
Occurring in:
  1. Bifunctional protein GlmU
The deposited structure of PDB entry 3d8v contains 1 copy of Pfam domain PF12804 (MobA-like NTP transferase domain) in Bifunctional protein GlmU. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005882
Domain description: Bifunctional protein GlmU
Occurring in:
  1. Bifunctional protein GlmU
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Bifunctional protein GlmU
IPR038009
Domain description: GlmU, C-terminal LbH domain
Occurring in:
  1. Bifunctional protein GlmU
IPR011004
Domain description: Trimeric LpxA-like superfamily
Occurring in:
  1. Bifunctional protein GlmU
IPR025877
Domain description: MobA-like NTP transferase
Occurring in:
  1. Bifunctional protein GlmU

Structure domains

CATH CATH domains
2.160.10.10
Class: Mainly Beta
Architecture: 3 Solenoid
Topology: UDP N-Acetylglucosamine Acyltransferase; domain 1
Homology: Hexapeptide repeat proteins
Occurring in:
  1. Bifunctional protein GlmU
The deposited structure of PDB entry 3d8v contains 1 copy of CATH domain 2.160.10.10 (UDP N-Acetylglucosamine Acyltransferase; domain 1) in Bifunctional protein GlmU. Showing 1 copy in chain A.
3.90.550.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Occurring in:
  1. Bifunctional protein GlmU
The deposited structure of PDB entry 3d8v contains 1 copy of CATH domain 3.90.550.10 (Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A) in Bifunctional protein GlmU. Showing 1 copy in chain A.

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