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Structural Basis of KChIP4a Modulation of Kv4.3 Slow Inactivation

X-ray diffraction
3Å resolution
PDB entry 3dd4 coloured by chain, front view.
PDB entry 3dd4 coloured by chain, side view.
PDB entry 3dd4 coloured by chain, top view.
Source organism: Mus musculus
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Kv channel-interacting protein 4
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Multimeric state: monomeric
Accessible surface area: 11150.26 Å2
Buried surface area: 170.96 Å2
Dissociation area: 42.86 Å2
Dissociation energy (ΔGdiss): 12.63 kcal/mol
Dissociation entropy (TΔSdiss): 0.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-180161
Monomeric assembly 1 of PDB entry 3dd4 coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 3dd4 coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 3dd4 coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 20%
No. subunits : 1
Symmetry : None
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3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : This biological assembly agrees with none of the predictions of PISA & EPPIC
Assembly 2
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Assembly Name: Kv channel-interacting protein 4
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Multimeric state: homo dimer
Accessible surface area: 18337.99 Å2
Buried surface area: 4309.48 Å2
Dissociation area: 1,983.79 Å2
Dissociation energy (ΔGdiss): 30.76 kcal/mol
Dissociation entropy (TΔSdiss): 13.19 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-180162
Homo dimeric assembly 2 of PDB entry 3dd4 coloured by chemically distinct molecules, front view.
Homo dimeric assembly 2 of PDB entry 3dd4 coloured by chemically distinct molecules, side view.
Homo dimeric assembly 2 of PDB entry 3dd4 coloured by chemically distinct molecules, top view.
    Assembly 2
Confidence : 96%
No. subunits : 2
Symmetry : C2
More details
3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : This biological assembly agrees with the prediction of both PISA & EPPIC

Macromolecules

Kv channel-interacting protein 4
Chain: A
Length: 229 amino acids
Theoretical weight: 26.53 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6PHZ8 (Residues: 52-250; Coverage: 80%)
  • Best match: Q6PHZ8-4 (Residues: 1-229)
Gene names: Calp, Kchip4, Kcnip4
Pfam:
InterPro:
CATH: EF-hand
Kv channel-interacting protein 4 in PDB entry 3dd4, assembly 1, front view.
Kv channel-interacting protein 4 in PDB entry 3dd4, assembly 1, side view.
Kv channel-interacting protein 4 in PDB entry 3dd4, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q6PHZ8  
122920406080100120140160180200220
 
100200
UniProt
Q6PHZ8
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Sequence conservation
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