3dds Citations

Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.

Abstract

Key binding interactions of the anthranilimide based glycogen phosphorylase a (GPa) inhibitor 2 from X-ray crystallography studies are described. This series of compounds bind to the AMP site of GP. Using the binding information the core and the phenyl urea moieties were optimized. This work culminated in the identification of compounds with single nanomolar potency as well as in vivo efficacy in a diabetic model.

Reviews - 3dds mentioned but not cited (2)

  1. The Structural Biology of Bcl-xL. Lee EF, Fairlie WD. Int J Mol Sci 20 E2234 (2019)
  2. Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening. Pereira ASP, Banegas-Luna AJ, Peña-García J, Pérez-Sánchez H, Apostolides Z. Molecules 24 E4030 (2019)

Articles - 3dds mentioned but not cited (16)



Reviews citing this publication (3)

  1. Glycogen phosphorylase inhibitors: a patent review (2008 - 2012). Gaboriaud-Kolar N, Skaltsounis AL. Expert Opin Ther Pat 23 1017-1032 (2013)
  2. Crystal structures of eukaryote glycosyltransferases reveal biologically relevant enzyme homooligomers. Harrus D, Kellokumpu S, Glumoff T. Cell Mol Life Sci 75 833-848 (2018)
  3. Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases. Li A, Benkoulouche M, Ladeveze S, Durand J, Cioci G, Laville E, Potocki-Veronese G. Int J Mol Sci 23 3043 (2022)

Articles citing this publication (7)