EC 1.1.1.62: 17-beta-estradiol 17-dehydrogenase
Reaction catalysed:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
Systematic name:
17-beta-estradiol:NAD(P)(+) 17-oxidoreductase
Alternative Name(s):
- 17-beta,20-alpha-hydroxysteroid dehydrogenase
- 17-beta-HSD
- 17-beta-estradiol dehydrogenase
- 17-beta-hydroxysteroid dehydrogenase
- 20-alpha-hydroxysteroid dehydrogenase
- Estradiol dehydrogenase
- Estrogen 17-oxidoreductase
- HSD17B7
EC 1.1.1.51: 3(or 17)-beta-hydroxysteroid dehydrogenase
Reaction catalysed:
Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H
Systematic name:
3(or 17)-beta-hydroxysteroid:NAD(P)(+) oxidoreductase
Alternative Name(s):
- 17-beta-hydroxy steroid dehydrogenase
- 17-ketoreductase
- 3-beta-hydroxy steroid dehydrogenase
- 3-beta-hydroxysteroid dehydrogenase
- Beta-hydroxy steroid dehydrogenase
GO terms
Biochemical function:
- estradiol binding
- 17-beta-hydroxysteroid dehydrogenase (NADP+) activity
- NADP+ binding
- NADP binding
- testosterone 17-beta-dehydrogenase (NADP+) activity
- testosterone dehydrogenase (NAD+) activity
- protein homodimerization activity
- small molecule binding
- testosterone dehydrogenase [NAD(P)+] activity
- oxidoreductase activity
- protein binding
- steroid binding
- estradiol 17-beta-dehydrogenase [NAD(P)+] activity
- catalytic activity
Protein family (Pfam)![The deposited structure of PDB entry 3dey contains 1 copy of Pfam domain PF00106 (short chain dehydrogenase) in 17-beta-hydroxysteroid dehydrogenase type 1. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/3dey_1_X_Pfam_PF00106_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3dey</span> contains 1 copy of Pfam domain <span class='highlight'>PF00106 (short chain dehydrogenase)</span> in <span class='highlight'>17-beta-hydroxysteroid dehydrogenase type 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 3dey contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in 17-beta-hydroxysteroid dehydrogenase type 1. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/3dey_1_X_CATH_3.40.50.720_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3dey</span> contains 1 copy of CATH domain <span class='highlight'>3.40.50.720 (Rossmann fold)</span> in <span class='highlight'>17-beta-hydroxysteroid dehydrogenase type 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")