3dm1 › Citations

Structural basis of the chromodomain of Cbx3 bound to methylated peptides from histone h1 and G9a.

Ruan J, Ouyang H, Amaya MF, Ravichandran M, Loppnau P, Min J, Zang J
PLoS One 7 e35376 (2012)
Cited: 22 times
EuropePMC logo PMID: 22514736

Abstract

Background

HP1 proteins are highly conserved heterochromatin proteins, which have been identified to be structural adapters assembling a variety of macromolecular complexes involved in regulation of gene expression, chromatin remodeling and heterochromatin formation. Much evidence shows that HP1 proteins interact with numerous proteins including methylated histones, histone methyltransferases and so on. Cbx3 is one of the paralogues of HP1 proteins, which has been reported to specifically recognize trimethylated histone H3K9 mark, and a consensus binding motif has been defined for the Cbx3 chromodomain.

Reviews - 3dm1 mentioned but not cited (1)

  1. Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives. Andreoli F, Barbosa AJ, Parenti MD, Del Rio A. Curr Pharm Des 19 578-613 (2013)

Articles - 3dm1 mentioned but not cited (6)

  1. Quantitative assessment of protein interaction with methyl-lysine analogues by hybrid computational and experimental approaches. Seeliger D, Soeroes S, Klingberg R, Schwarzer D, Grubmüller H, Fischle W. ACS Chem. Biol. 7 150-154 (2012)
  2. Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9. Li J, Li Z, Ruan J, Xu C, Tong Y, Pan PW, Tempel W, Crombet L, Min J, Zang J. PLoS ONE 6 e25104 (2011)
  3. Structural basis of the chromodomain of Cbx3 bound to methylated peptides from histone h1 and G9a. Ruan J, Ouyang H, Amaya MF, Ravichandran M, Loppnau P, Min J, Zang J. PLoS One 7 e35376 (2012)
  4. Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ. Velez G, Lin M, Christensen T, Faubion WA, Lomberk G, Urrutia R. J Mol Model 22 12 (2016)
  5. Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain. Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G. PLoS ONE 15 e0217452 (2020)
  6. High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression. Veggiani G, Villaseñor R, Martyn GD, Tang JQ, Krone MW, Gu J, Chen C, Waters ML, Pearce KH, Baubec T, Sidhu SS. Nat Commun 13 6975 (2022)


Reviews citing this publication (5)

  1. The functional diversity of protein lysine methylation. Lanouette S, Mongeon V, Figeys D, Couture JF. Mol. Syst. Biol. 10 724 (2014)
  2. HP1a: a structural chromosomal protein regulating transcription. Eissenberg JC, Elgin SC. Trends Genet. 30 103-110 (2014)
  3. Epigenetic targets and drug discovery: part 1: histone methylation. Liu Y, Liu K, Qin S, Xu C, Min J. Pharmacol. Ther. 143 275-294 (2014)
  4. One, two, three: how histone methylation is read. Fischle W. Epigenomics 4 641-653 (2012)
  5. The missing linker: emerging trends for H1 variant-specific functions. Prendergast L, Reinberg D. Genes Dev 35 40-58 (2021)

Articles citing this publication (10)

  1. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. Nature 496 377-381 (2013)
  2. RNA sequencing identifies novel markers of non-small cell lung cancer. Han SS, Kim WJ, Hong Y, Hong SH, Lee SJ, Ryu DR, Lee W, Cho YH, Lee S, Ryu YJ, Won JY, Rhee H, Park JH, Jang SJ, Lee JS, Choi CM, Lee JC, Lee SD, Oh YM. Lung Cancer 84 229-235 (2014)
  3. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, Feeney CM, Taylor JE, Creech AL, Qiao JW, Szanto A, Das PP, Chevrier N, Cifuentes-Rojas C, Orkin SH, Carr SA, Jaffe JD, Mertins P, Lee JT. Mol. Cell Proteomics 14 1435-1446 (2015)
  4. Structural plasticity in human heterochromatin protein 1β. Munari F, Rezaei-Ghaleh N, Xiang S, Fischle W, Zweckstetter M. PLoS ONE 8 e60887 (2013)
  5. Structure of the JmjC-domain-containing protein JMJD5. Wang H, Zhou X, Wu M, Wang C, Zhang X, Tao Y, Chen N, Zang J. Acta Crystallogr. D Biol. Crystallogr. 69 1911-1920 (2013)
  6. Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation. Tomaz RA, Harman JL, Karimlou D, Weavers L, Fritsch L, Bou-Kheir T, Bell E, Del Valle Torres I, Niakan KK, Fisher C, Joshi O, Stunnenberg HG, Curry E, Ait-Si-Ali S, Jørgensen HF, Azuara V. Development 144 567-579 (2017)
  7. Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis. Bhanu NV, Sidoli S, Yuan ZF, Molden RC, Garcia BA. J Biol Chem 294 8296-8308 (2019)
  8. The interplay between H2A.Z and H3K9 methylation in regulating HP1α binding to linker histone-containing chromatin. Ryan DP, Tremethick DJ. Nucleic Acids Res. 46 9353-9366 (2018)
  9. CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression. Zhang H, Yu H, Ren D, Sun Y, Guo F, Cai H, Zhou C, Zhou Y, Jin X, Wu H. Int J Biol Sci 18 3484-3497 (2022)
  10. CBX3/HP1γ promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma. Zhong X, Kan A, Zhang W, Zhou J, Zhang H, Chen J, Tang S. Aging (Albany NY) 11 5483-5497 (2019)


Quick links