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STRUCTURE OF DMSO REDUCTASE FROM RHODOBACTER CAPSULATUS AT PH 7.0

Source organism: Rhodobacter capsulatus
Biochemical function: molybdopterin cofactor binding
Biological process: not assigned
Cellular component: not assigned

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EC 1.8.5.3: Respiratory dimethylsulfoxide reductase

Reaction catalysed:
Dimethylsulfide + menaquinone + H(2)O = dimethylsulfoxide + menaquinol
Systematic name:
Dimethyl sulfide:menaquinone oxidoreductase
Alternative Name(s):
  • DMSO reductase
  • Dimethylsulfoxide reductase

EC 1.7.2.3: Trimethylamine-N-oxide reductase

Reaction catalysed:
Trimethylamine + 2 (ferricytochrome c)-subunit + H(2)O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H(+)
Systematic name:
Trimethylamine:cytochrome c oxidoreductase
Alternative Name(s):
  • TMAO reductase
  • TOR
  • Trimethylamine-N-oxide reductase (cytochrome c)

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01568
Domain description: Molydopterin dinucleotide binding domain
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
The deposited structure of PDB entry 3dmr contains 1 copy of Pfam domain PF01568 (Molydopterin dinucleotide binding domain) in Dimethyl sulfoxide/trimethylamine N-oxide reductase. Showing 1 copy in chain A.

PF00384
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
The deposited structure of PDB entry 3dmr contains 1 copy of Pfam domain PF00384 (Molybdopterin oxidoreductase) in Dimethyl sulfoxide/trimethylamine N-oxide reductase. Showing 1 copy in chain A.

PF18364
Domain description: Molybdopterin oxidoreductase N-terminal domain
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
The deposited structure of PDB entry 3dmr contains 1 copy of Pfam domain PF18364 (Molybdopterin oxidoreductase N-terminal domain) in Dimethyl sulfoxide/trimethylamine N-oxide reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006655
Domain description: Molybdopterin oxidoreductase, prokaryotic, conserved site
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
IPR006657
Domain description: Molybdopterin dinucleotide-binding domain
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
IPR041954
Domain description: Trimethylamine-N-oxide reductase-like, molybdopterin-binding domain
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
IPR009010
Domain description: Aspartate decarboxylase-like domain superfamily
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
IPR006656
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
IPR006658
Domain description: Molybdopterin guanine dinucleotide-containing S/N-oxide reductase
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
IPR041460
Domain description: Molybdopterin oxidoreductase, N-terminal
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
IPR006311
Domain description: Twin-arginine translocation pathway, signal sequence
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase

Structure domains

CATH CATH domains
3.40.50.740
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
The deposited structure of PDB entry 3dmr contains 1 copy of CATH domain 3.40.50.740 (Rossmann fold) in Dimethyl sulfoxide/trimethylamine N-oxide reductase. Showing 1 copy in chain A.
3.90.55.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Dimethylsulfoxide Reductase; domain 3
Homology: Dimethylsulfoxide Reductase, domain 3
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
The deposited structure of PDB entry 3dmr contains 1 copy of CATH domain 3.90.55.10 (Dimethylsulfoxide Reductase; domain 3) in Dimethyl sulfoxide/trimethylamine N-oxide reductase. Showing 1 copy in chain A.
3.40.228.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Dimethylsulfoxide Reductase; domain 2
Homology: Dimethylsulfoxide Reductase, domain 2
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
The deposited structure of PDB entry 3dmr contains 1 copy of CATH domain 3.40.228.10 (Dimethylsulfoxide Reductase; domain 2) in Dimethyl sulfoxide/trimethylamine N-oxide reductase. Showing 1 copy in chain A.
2.40.40.20
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Barwin-like endoglucanases
Homology: Barwin-like endoglucanases
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
The deposited structure of PDB entry 3dmr contains 1 copy of CATH domain 2.40.40.20 (Barwin-like endoglucanases) in Dimethyl sulfoxide/trimethylamine N-oxide reductase. Showing 1 copy in chain A.
SCOP SCOP annotations
50696
Class: All beta proteins
Fold: Double psi beta-barrel
Superfamily: ADC-like
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
The deposited structure of PDB entry 3dmr contains 1 copy of SCOP domain 50696 (Formate dehydrogenase/DMSO reductase, C-terminal domain) in Dimethyl sulfoxide/trimethylamine N-oxide reductase. Showing 1 copy in chain A.
53707
Class: Alpha and beta proteins (a/b)
Fold: Formate dehydrogenase/DMSO reductase, domains 1-3
Superfamily: Formate dehydrogenase/DMSO reductase, domains 1-3
Occurring in:
  1. Dimethyl sulfoxide/trimethylamine N-oxide reductase
The deposited structure of PDB entry 3dmr contains 1 copy of SCOP domain 53707 (Formate dehydrogenase/DMSO reductase, domains 1-3) in Dimethyl sulfoxide/trimethylamine N-oxide reductase. Showing 1 copy in chain A.

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