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Crystal Structure of 7,8 Diaminopelargonic Acid Synthase Apoenzyme in Bacillus subtilis

Source organism: Bacillus subtilis
Biochemical function: pyridoxal phosphate binding
Biological process: biotin biosynthetic process
Cellular component: cytoplasm

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EC 2.6.1.105: Lysine--8-amino-7-oxononanoate transaminase

Reaction catalysed:
L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate
Systematic name:
L-lysine:8-amino-7-oxononanoate aminotransferase
Alternative Name(s):
  • BioA (gene name)
  • BioK (gene name)
  • DAPA aminotransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00202
Domain description: Aminotransferase class-III
Occurring in:
  1. L-Lysine--8-amino-7-oxononanoate transaminase
The deposited structure of PDB entry 3drd contains 2 copies of Pfam domain PF00202 (Aminotransferase class-III) in L-Lysine--8-amino-7-oxononanoate transaminase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005814
Domain description: Aminotransferase class-III
Occurring in:
  1. L-Lysine--8-amino-7-oxononanoate transaminase
IPR005815
Domain description: Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA
Occurring in:
  1. L-Lysine--8-amino-7-oxononanoate transaminase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. L-Lysine--8-amino-7-oxononanoate transaminase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. L-Lysine--8-amino-7-oxononanoate transaminase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. L-Lysine--8-amino-7-oxononanoate transaminase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. L-Lysine--8-amino-7-oxononanoate transaminase
The deposited structure of PDB entry 3drd contains 2 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in L-Lysine--8-amino-7-oxononanoate transaminase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. L-Lysine--8-amino-7-oxononanoate transaminase
The deposited structure of PDB entry 3drd contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in L-Lysine--8-amino-7-oxononanoate transaminase. Showing 1 copy in chain A.

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