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E. coli (lacZ) beta-galactosidase (H418N)

Source organism: Escherichia coli K-12
Biochemical function: metal ion binding
Biological process: catabolic process
Cellular component: beta-galactosidase complex

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EC 3.2.1.23: Beta-galactosidase

Reaction catalysed:
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides
Systematic name:
Beta-D-galactoside galactohydrolase
Alternative Name(s):
  • Beta-D-galactanase
  • Beta-D-lactosidase
  • Beta-lactosidase
  • Exo-(1->4)-beta-D-galactanase
  • Hydrolact
  • Lactase
  • Lactozym
  • Maxilact
  • Oryzatym
  • S 2107
  • Sumiklat
  • Trilactase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02929
Domain description: Beta galactosidase small chain
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3dyp contains 4 copies of Pfam domain PF02929 (Beta galactosidase small chain) in Beta-galactosidase. Showing 1 copy in chain A.

PF16353
Domain description: Beta-galactosidase, domain 4
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3dyp contains 4 copies of Pfam domain PF16353 (Beta-galactosidase, domain 4) in Beta-galactosidase. Showing 1 copy in chain A.

PF02836
Domain description: Glycosyl hydrolases family 2, TIM barrel domain
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3dyp contains 4 copies of Pfam domain PF02836 (Glycosyl hydrolases family 2, TIM barrel domain) in Beta-galactosidase. Showing 1 copy in chain A.

PF00703
Domain description: Glycosyl hydrolases family 2
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3dyp contains 4 copies of Pfam domain PF00703 (Glycosyl hydrolases family 2) in Beta-galactosidase. Showing 1 copy in chain A.

PF02837
Domain description: Glycosyl hydrolases family 2, sugar binding domain
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3dyp contains 4 copies of Pfam domain PF02837 (Glycosyl hydrolases family 2, sugar binding domain) in Beta-galactosidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006101
Domain description: Glycoside hydrolase, family 2
Occurring in:
  1. Beta-galactosidase
IPR004199
Domain description: Beta galactosidase small chain/ domain 5
Occurring in:
  1. Beta-galactosidase
IPR036156
Domain description: Beta-Galactosidase/glucuronidase domain superfamily
Occurring in:
  1. Beta-galactosidase
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Beta-galactosidase
IPR011013
Domain description: Galactose mutarotase-like domain superfamily
Occurring in:
  1. Beta-galactosidase
IPR014718
Domain description: Glycoside hydrolase-type carbohydrate-binding
Occurring in:
  1. Beta-galactosidase
IPR032312
Domain description: Beta-galactosidase, domain 4
Occurring in:
  1. Beta-galactosidase
IPR023232
Domain description: Glycoside hydrolase, family 2, active site
Occurring in:
  1. Beta-galactosidase
IPR023230
Domain description: Glycoside hydrolase, family 2, conserved site
Occurring in:
  1. Beta-galactosidase
IPR006103
Domain description: Glycoside hydrolase family 2, catalytic domain
Occurring in:
  1. Beta-galactosidase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Beta-galactosidase
IPR006102
Domain description: Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich
Occurring in:
  1. Beta-galactosidase
IPR006104
Domain description: Glycosyl hydrolases family 2, sugar binding domain
Occurring in:
  1. Beta-galactosidase
IPR008979
Domain description: Galactose-binding-like domain superfamily
Occurring in:
  1. Beta-galactosidase
IPR023933
Domain description: Glycoside hydrolase, family 2, beta-galactosidase
Occurring in:
  1. Beta-galactosidase

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3dyp contains 8 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-galactosidase. Showing 2 copies in chain A.
2.70.98.10
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Beta-galactosidase; Chain A, domain 5
Homology: Beta-galactosidase; Chain A, domain 5
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3dyp contains 4 copies of CATH domain 2.70.98.10 (Beta-galactosidase; Chain A, domain 5) in Beta-galactosidase. Showing 1 copy in chain A.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3dyp contains 4 copies of CATH domain 3.20.20.80 (TIM Barrel) in Beta-galactosidase. Showing 1 copy in chain A.
2.60.120.260
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Galactose-binding domain-like
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3dyp contains 4 copies of CATH domain 2.60.120.260 (Jelly Rolls) in Beta-galactosidase. Showing 1 copy in chain A.

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