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The catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan

Source organism: Gallus gallus
Biochemical function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological process: aromatic amino acid metabolic process
Cellular component: not assigned

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EC 1.14.16.4: Tryptophan 5-monooxygenase

Reaction catalysed:
L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
Systematic name:
L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
Alternative Name(s):
  • Indoleacetic acid-5-hydroxylase
  • L-tryptophan hydroxylase
  • Tryptophan 5-hydroxylase
  • Tryptophan hydroxylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00351
Domain description: Biopterin-dependent aromatic amino acid hydroxylase
Occurring in:
  1. Tryptophan 5-hydroxylase 1
The deposited structure of PDB entry 3e2t contains 1 copy of Pfam domain PF00351 (Biopterin-dependent aromatic amino acid hydroxylase) in Tryptophan 5-hydroxylase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019774
Domain description: Aromatic amino acid hydroxylase, C-terminal
Occurring in:
  1. Tryptophan 5-hydroxylase 1
IPR018301
Domain description: Aromatic amino acid hydroxylase, iron/copper binding site
Occurring in:
  1. Tryptophan 5-hydroxylase 1
IPR041904
Domain description: Tryptophan 5-hydroxylase, catalytic domain
Occurring in:
  1. Tryptophan 5-hydroxylase 1
IPR036329
Domain description: Aromatic amino acid monoxygenase, C-terminal domain superfamily
Occurring in:
  1. Tryptophan 5-hydroxylase 1
IPR001273
Domain description: Aromatic amino acid hydroxylase
Occurring in:
  1. Tryptophan 5-hydroxylase 1
IPR036951
Domain description: Aromatic amino acid hydroxylase superfamily
Occurring in:
  1. Tryptophan 5-hydroxylase 1

Structure domain

CATH CATH domain
1.10.800.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Phenylalanine Hydroxylase
Homology: Aromatic amino acid hydroxylase
Occurring in:
  1. Tryptophan 5-hydroxylase 1
The deposited structure of PDB entry 3e2t contains 1 copy of CATH domain 1.10.800.10 (Phenylalanine Hydroxylase) in Tryptophan 5-hydroxylase 1. Showing 1 copy in chain A.

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