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Human phosphoserine aminotransferase in complex with PLP

Source organism: Homo sapiens
Biochemical function: identical protein binding
Biological process: pyridoxine biosynthetic process
Cellular component: extracellular exosome

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EC 2.6.1.52: Phosphoserine transaminase

Reaction catalysed:
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate
Systematic name:
O-phospho-L-serine:2-oxoglutarate aminotransferase
Alternative Name(s):
  • 3-O-phospho-L-serine:2-oxoglutarate aminotransferase
  • 3-phosphoserine aminotransferase
  • 3PHP transaminase
  • Hydroxypyruvic phosphate--glutamic transaminase
  • L-phosphoserine aminotransferase
  • PSAT
  • PdxC
  • Phosphohydroxypyruvate transaminase
  • Phosphohydroxypyruvic--glutamic transaminase
  • Phosphoserine aminotransferase
  • SerC

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00266
Domain description: Aminotransferase class-V
Occurring in:
  1. Phosphoserine aminotransferase
The deposited structure of PDB entry 3e77 contains 3 copies of Pfam domain PF00266 (Aminotransferase class-V) in Phosphoserine aminotransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR022278
Domain description: Phosphoserine aminotransferase
Occurring in:
  1. Phosphoserine aminotransferase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Phosphoserine aminotransferase
IPR020578
Domain description: Aminotransferase class-V, pyridoxal-phosphate binding site
Occurring in:
  1. Phosphoserine aminotransferase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Phosphoserine aminotransferase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Phosphoserine aminotransferase
IPR000192
Domain description: Aminotransferase class V domain
Occurring in:
  1. Phosphoserine aminotransferase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Phosphoserine aminotransferase
The deposited structure of PDB entry 3e77 contains 3 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Phosphoserine aminotransferase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Phosphoserine aminotransferase
The deposited structure of PDB entry 3e77 contains 3 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Phosphoserine aminotransferase. Showing 1 copy in chain A.

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