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Structure of human prostaglandin D-synthase (hGSTS1-1) in complex with nocodazole

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: negative regulation of male germ cell proliferation
Cellular component: intracellular membrane-bounded organelle

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EC 5.3.99.2: Prostaglandin-D synthase

Reaction catalysed:
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
Systematic name:
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
Alternative Name(s):
  • (5,13)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
  • (5,13)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase
  • PGD2 synthase
  • PGH-PGD isomerase
  • Prostaglandin D synthetase
  • Prostaglandin D2 synthase
  • Prostaglandin endoperoxide Delta-isomerase
  • Prostaglandin-H(2) Delta-isomerase
  • Prostaglandin-R-prostaglandin D isomerase

EC 2.5.1.18: Glutathione transferase

Reaction catalysed:
RX + glutathione = HX + R-S-glutathione
Systematic name:
RX:glutathione R-transferase
Alternative Name(s):
  • Glutathione S-alkyl transferase
  • Glutathione S-alkyltransferase
  • Glutathione S-aralkyltransferase
  • Glutathione S-aryltransferase
  • Glutathione S-transferase
  • S-(hydroxyalkyl)glutathione lyase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF14497
Domain description: Glutathione S-transferase, C-terminal domain
Occurring in:
  1. Hematopoietic prostaglandin D synthase
The deposited structure of PDB entry 3ee2 contains 2 copies of Pfam domain PF14497 (Glutathione S-transferase, C-terminal domain) in Hematopoietic prostaglandin D synthase. Showing 1 copy in chain A.

PF02798
Domain description: Glutathione S-transferase, N-terminal domain
Occurring in:
  1. Hematopoietic prostaglandin D synthase
The deposited structure of PDB entry 3ee2 contains 2 copies of Pfam domain PF02798 (Glutathione S-transferase, N-terminal domain) in Hematopoietic prostaglandin D synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004045
Domain description: Glutathione S-transferase, N-terminal
Occurring in:
  1. Hematopoietic prostaglandin D synthase
IPR004046
Domain description: Glutathione S-transferase, C-terminal
Occurring in:
  1. Hematopoietic prostaglandin D synthase
IPR010987
Domain description: Glutathione S-transferase, C-terminal-like
Occurring in:
  1. Hematopoietic prostaglandin D synthase
IPR036282
Domain description: Glutathione S-transferase, C-terminal domain superfamily
Occurring in:
  1. Hematopoietic prostaglandin D synthase
IPR040079
Domain description: Glutathione transferase family
Occurring in:
  1. Hematopoietic prostaglandin D synthase
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. Hematopoietic prostaglandin D synthase

Structure domains

CATH CATH domains
3.40.30.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Glutaredoxin
Homology: Glutaredoxin
Occurring in:
  1. Hematopoietic prostaglandin D synthase
The deposited structure of PDB entry 3ee2 contains 2 copies of CATH domain 3.40.30.10 (Glutaredoxin) in Hematopoietic prostaglandin D synthase. Showing 1 copy in chain A.
1.20.1050.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Homology: Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Occurring in:
  1. Hematopoietic prostaglandin D synthase
The deposited structure of PDB entry 3ee2 contains 2 copies of CATH domain 1.20.1050.10 (Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2) in Hematopoietic prostaglandin D synthase. Showing 1 copy in chain A.
SCOP SCOP annotations
47617
Class: All alpha proteins
Fold: GST C-terminal domain-like
Superfamily: GST C-terminal domain-like
Occurring in:
  1. Hematopoietic prostaglandin D synthase
The deposited structure of PDB entry 3ee2 contains 2 copies of SCOP domain 47617 (Glutathione S-transferase (GST), C-terminal domain) in Hematopoietic prostaglandin D synthase. Showing 1 copy in chain A.
52862
Class: Alpha and beta proteins (a/b)
Fold: Thioredoxin fold
Superfamily: Thioredoxin-like
Occurring in:
  1. Hematopoietic prostaglandin D synthase
The deposited structure of PDB entry 3ee2 contains 2 copies of SCOP domain 52862 (Glutathione S-transferase (GST), N-terminal domain) in Hematopoietic prostaglandin D synthase. Showing 1 copy in chain A.

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