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Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.

Mancias JD, Goldberg J
EMBO J 27 2918-28 (2008)
Related entries: 3eg9, 3egd, 3egx, 3eh1, 3eh2

Cited: 136 times
EuropePMC logo PMID: 18843296

Abstract

Genomic analysis shows that the increased complexity of trafficking pathways in mammalian cells involves an expansion of the number of SNARE, Rab and COP proteins. Thus, the human genome encodes four forms of Sec24, the cargo selection subunit of the COPII vesicular coat, and this is proposed to increase the range of cargo accommodated by human COPII-coated vesicles. In this study, we combined X-ray crystallographic and biochemical analysis with functional assays of cargo packaging into COPII vesicles to establish molecular mechanisms for cargo discrimination by human Sec24 subunits. A conserved IxM packaging signal binds in a surface groove of Sec24c and Sec24d, but the groove is occluded in the Sec24a and Sec24b subunits. Conversely, LxxLE class transport signals and the DxE signal of VSV glycoprotein are selectively bound by Sec24a and Sec24b subunits. A comparative analysis of crystal structures of the four human Sec24 isoforms establishes the structural determinants for discrimination among these transport signals, and provides a framework to understand how an expansion of coat subunits extends the range of cargo proteins packaged into COPII-coated vesicles.

Reviews - 3efo mentioned but not cited (1)

  1. Dephosphorylating eukaryotic RNA polymerase II. Mayfield JE, Burkholder NT, Zhang YJ. Biochim Biophys Acta 1864 372-387 (2016)

Articles - 3efo mentioned but not cited (5)

  1. Mutations in SEC24D, encoding a component of the COPII machinery, cause a syndromic form of osteogenesis imperfecta. Garbes L, Kim K, Rieß A, Hoyer-Kuhn H, Beleggia F, Bevot A, Kim MJ, Huh YH, Kweon HS, Savarirayan R, Amor D, Kakadia PM, Lindig T, Kagan KO, Becker J, Boyadjiev SA, Wollnik B, Semler O, Bohlander SK, Kim J, Netzer C. Am J Hum Genet 96 432-439 (2015)
  2. The structure of the COPII transport-vesicle coat assembled on membranes. Zanetti G, Prinz S, Daum S, Meister A, Schekman R, Bacia K, Briggs JA. Elife 2 e00951 (2013)
  3. The ULK1-FBXW5-SEC23B nexus controls autophagy. Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, Florens L, Washburn MP, Cavasotto CN, Fenyö D, Cuervo AM, Rossi M, Pagano M. Elife 7 e42253 (2018)
  4. Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR. Bruno A, Costantino G, de Fabritiis G, Pastor M, Selent J. PLoS One 7 e42023 (2012)
  5. 'Hot' macromolecular crystals. Koclega KD, Chruszcz M, Zimmerman MD, Bujacz G, Minor W. Cryst Growth Des 10 580 (2009)


Reviews citing this publication (46)

  1. COPII and the regulation of protein sorting in mammals. Zanetti G, Pahuja KB, Studer S, Shim S, Schekman R. Nat Cell Biol 14 20-28 (2011)
  2. Protein sorting at the ER-Golgi interface. Gomez-Navarro N, Miller E. J Cell Biol 215 769-778 (2016)
  3. Vesicle-mediated export from the ER: COPII coat function and regulation. D'Arcangelo JG, Stahmer KR, Miller EA. Biochim Biophys Acta 1833 2464-2472 (2013)
  4. Vesicle coats: structure, function, and general principles of assembly. Faini M, Beck R, Wieland FT, Briggs JA. Trends Cell Biol 23 279-288 (2013)
  5. COPII and COPI traffic at the ER-Golgi interface. Szul T, Sztul E. Physiology (Bethesda) 26 348-364 (2011)
  6. Regulation of coat assembly--sorting things out at the ER. Miller EA, Barlowe C. Curr Opin Cell Biol 22 447-453 (2010)
  7. The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi. Lord C, Ferro-Novick S, Miller EA. Cold Spring Harb Perspect Biol 5 a013367 (2013)
  8. Assembly of COPI and COPII Vesicular Coat Proteins on Membranes. Béthune J, Wieland FT. Annu Rev Biophys 47 63-83 (2018)
  9. COPII-mediated trafficking at the ER/ERGIC interface. Peotter J, Kasberg W, Pustova I, Audhya A. Traffic 20 491-503 (2019)
  10. Biogenesis, trafficking and up-regulation of nicotinic ACh receptors. Colombo SF, Mazzo F, Pistillo F, Gotti C. Biochem Pharmacol 86 1063-1073 (2013)
  11. Vesicle-mediated ER export of proteins and lipids. Gillon AD, Latham CF, Miller EA. Biochim Biophys Acta 1821 1040-1049 (2012)
  12. New insights into the structural mechanisms of the COPII coat. Russell C, Stagg SM. Traffic 11 303-310 (2010)
  13. Insights into plant plasma membrane aquaporin trafficking. Hachez C, Besserer A, Chevalier AS, Chaumont F. Trends Plant Sci 18 344-352 (2013)
  14. Coatopathies: Genetic Disorders of Protein Coats. Dell'Angelica EC, Bonifacino JS. Annu Rev Cell Dev Biol 35 131-168 (2019)
  15. The yeast Golgi apparatus: insights and mysteries. Papanikou E, Glick BS. FEBS Lett 583 3746-3751 (2009)
  16. Cargo adaptors: structures illuminate mechanisms regulating vesicle biogenesis. Paczkowski JE, Richardson BC, Fromme JC. Trends Cell Biol 25 408-416 (2015)
  17. The back and forth of cargo exit from the endoplasmic reticulum. Geva Y, Schuldiner M. Curr Biol 24 R130-6 (2014)
  18. The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol. Poirier S, Mayer G. Drug Des Devel Ther 7 1135-1148 (2013)
  19. Control of organelle size: the Golgi complex. Sengupta D, Linstedt AD. Annu Rev Cell Dev Biol 27 57-77 (2011)
  20. Traffic routes and signals for the tonoplast. Pedrazzini E, Komarova NY, Rentsch D, Vitale A. Traffic 14 622-628 (2013)
  21. Psychiatric drugs bind to classical targets within early exocytotic pathways: therapeutic effects. Lester HA, Miwa JM, Srinivasan R. Biol Psychiatry 72 907-915 (2012)
  22. Cellular and molecular biology of glycosphingolipid glycosylation. Maccioni HJ, Quiroga R, Ferrari ML. J Neurochem 117 589-602 (2011)
  23. Trafficking mechanisms of extracellular matrix macromolecules: insights from vertebrate development and human diseases. Unlu G, Levic DS, Melville DB, Knapik EW. Int J Biochem Cell Biol 47 57-67 (2014)
  24. Stx5-Mediated ER-Golgi Transport in Mammals and Yeast. Linders PT, Horst CV, Beest MT, van den Bogaart G. Cells 8 E780 (2019)
  25. Mechanisms for exporting large-sized cargoes from the endoplasmic reticulum. Saito K, Katada T. Cell Mol Life Sci 72 3709-3720 (2015)
  26. Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Isacoff EY, Jan LY, Minor DL. Neuron 80 658-674 (2013)
  27. From cradle to twilight: the carboxyl terminus directs the fate of the A(2A)-adenosine receptor. Keuerleber S, Gsandtner I, Freissmuth M. Biochim Biophys Acta 1808 1350-1357 (2011)
  28. Emergent properties of proteostasis-COPII coupled systems in human health and disease. Routledge KE, Gupta V, Balch WE. Mol Membr Biol 27 385-397 (2010)
  29. Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy. Cui L, Li H, Xi Y, Hu Q, Liu H, Fan J, Xiang Y, Zhang X, Shui W, Lai Y. Mol Biomed 3 29 (2022)
  30. Organization of the synthesis of glycolipid oligosaccharides in the Golgi complex. Maccioni HJ, Quiroga R, Spessott W. FEBS Lett 585 1691-1698 (2011)
  31. ER-to-Golgi Trafficking and Its Implication in Neurological Diseases. Wang B, Stanford KR, Kundu M. Cells 9 E408 (2020)
  32. Inherited hematological disorders due to defects in coat protein (COP)II complex. Russo R, Esposito MR, Iolascon A. Am J Hematol 88 135-140 (2013)
  33. Traffic jams in fish bones: ER-to-Golgi protein transport during zebrafish development. Melville DB, Knapik EW. Cell Adh Migr 5 114-118 (2011)
  34. The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3. Kilisch M, Lytovchenko O, Schwappach B, Renigunta V, Daut J. Pflugers Arch 467 1105-1120 (2015)
  35. Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases. Tang VT, Ginsburg D. J Clin Invest 133 e163838 (2023)
  36. Export Control: Post-transcriptional Regulation of the COPII Trafficking Pathway. Bisnett BJ, Condon BM, Lamb CH, Georgiou GR, Boyce M. Front Cell Dev Biol 8 618652 (2020)
  37. Surf4, cargo trafficking, lipid metabolism, and therapeutic implications. Shen Y, Gu HM, Qin S, Zhang DW. J Mol Cell Biol 14 mjac063 (2023)
  38. Cellular assays for drug discovery in genetic disorders of intracellular trafficking. De Matteis MA, Vicinanza M, Venditti R, Wilson C. Annu Rev Genomics Hum Genet 14 159-190 (2013)
  39. Critical Determinants in ER-Golgi Trafficking of Enzymes Involved in Glycosylation. Zhang N, Zabotina OA. Plants (Basel) 11 428 (2022)
  40. Regulation of α2B-Adrenerigc Receptor Export Trafficking by Specific Motifs. Wu G, Davis JE, Zhang M. Prog Mol Biol Transl Sci 132 227-244 (2015)
  41. How to Avoid a No-Deal ER Exit. Anelli T, Panina-Bordignon P. Cells 8 E1051 (2019)
  42. Conventional and Unconventional Protein Secretion in Yeast and Animal Cells. Tang X, Guo Y. Methods Mol Biol 2841 1-17 (2024)
  43. First Case of a Dominant De Novo <i>SEC23A</i> Mutation with Neurological and Psychiatric Features: New Insights into Cranio-Lenticulo-Sutural Dysplasia with Literature Review. Minale EMP, De Falco A, Agolini E, Novelli A, Russo R, Andolfo I, Iolascon A, Piscopo C. Genes (Basel) 15 130 (2024)
  44. Identified and potential internalization signals involved in trafficking and regulation of Na+/K+ ATPase activity. Hodeify R, Kreydiyyeh S, Zaid LMJ. Mol Cell Biochem 479 1583-1598 (2024)
  45. Impact of interorganelle coordination between the conventional early secretory pathway and autophagy in cellular homeostasis and stress response. Tapia D, Cavieres VA, Burgos PV, Cancino J. Front Cell Dev Biol 11 1069256 (2023)
  46. New agents to reduce cholesterol levels: implications for nephrologists. Del Vecchio L, Baragetti I, Locatelli F. Nephrol Dial Transplant 35 213-218 (2020)

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  1. Structure of coatomer cage proteins and the relationship among COPI, COPII, and clathrin vesicle coats. Lee C, Goldberg J. Cell 142 123-132 (2010)
  2. Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. Wilson DG, Phamluong K, Li L, Sun M, Cao TC, Liu PS, Modrusan Z, Sandoval WN, Rangell L, Carano RA, Peterson AS, Solloway MJ. J Cell Biol 193 935-951 (2011)
  3. Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. Srinivasan R, Pantoja R, Moss FJ, Mackey ED, Son CD, Miwa J, Lester HA. J Gen Physiol 137 59-79 (2011)
  4. COPII - a flexible vesicle formation system. Miller EA, Schekman R. Curr Opin Cell Biol 25 420-427 (2013)
  5. Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. Sarmah S, Barrallo-Gimeno A, Melville DB, Topczewski J, Solnica-Krezel L, Knapik EW. PLoS One 5 e10367 (2010)
  6. A missense mutation in the Arabidopsis COPII coat protein Sec24A induces the formation of clusters of the endoplasmic reticulum and Golgi apparatus. Faso C, Chen YN, Tamura K, Held M, Zemelis S, Marti L, Saravanan R, Hummel E, Kung L, Miller E, Hawes C, Brandizzi F. Plant Cell 21 3655-3671 (2009)
  7. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D. Elife 2 e00444 (2013)
  8. Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI. Fujita M, Watanabe R, Jaensch N, Romanova-Michaelides M, Satoh T, Kato M, Riezman H, Yamaguchi Y, Maeda Y, Kinoshita T. J Cell Biol 194 61-75 (2011)
  9. Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat. Kung LF, Pagant S, Futai E, D'Arcangelo JG, Buchanan R, Dittmar JC, Reid RJ, Rothstein R, Hamamoto S, Snapp EL, Schekman R, Miller EA. EMBO J 31 1014-1027 (2012)
  10. Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation. Cattin-Ortolá J, Welch LG, Maslen SL, Papa G, James LC, Munro S. Nat Commun 12 5333 (2021)
  11. TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats. Ma W, Goldberg J. Proc Natl Acad Sci U S A 113 10061-10066 (2016)
  12. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M. J Biol Chem 286 16482-16490 (2011)
  13. Trans-Golgi network-located AP1 gamma adaptins mediate dileucine motif-directed vacuolar targeting in Arabidopsis. Wang X, Cai Y, Wang H, Zeng Y, Zhuang X, Li B, Jiang L, Jiang L. Plant Cell 26 4102-4118 (2014)
  14. A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export. Dong C, Nichols CD, Guo J, Huang W, Lambert NA, Wu G. Traffic 13 857-868 (2012)
  15. A recombinant BBSome core complex and how it interacts with ciliary cargo. Klink BU, Zent E, Juneja P, Kuhlee A, Raunser S, Wittinghofer A. Elife 6 e27434 (2017)
  16. Sec24 is a coincidence detector that simultaneously binds two signals to drive ER export. Pagant S, Wu A, Edwards S, Diehl F, Miller EA. Curr Biol 25 403-412 (2015)
  17. Sec24C is an HIV-1 host dependency factor crucial for virus replication. Rebensburg SV, Wei G, Larue RC, Lindenberger J, Francis AC, Annamalai AS, Morrison J, Shkriabai N, Huang SW, KewalRamani V, Poeschla EM, Melikyan GB, Kvaratskhelia M. Nat Microbiol 6 435-444 (2021)
  18. Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome. Guo T, Chung JH, Wang T, McDonald-McGinn DM, Kates WR, Hawuła W, Coleman K, Zackai E, Emanuel BS, Morrow BE. Am J Hum Genet 97 869-877 (2015)
  19. sec24d encoding a component of COPII is essential for vertebra formation, revealed by the analysis of the medaka mutant, vbi. Ohisa S, Inohaya K, Takano Y, Kudo A. Dev Biol 342 85-95 (2010)
  20. Di-acidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface. Zhang X, Dong C, Wu QJ, Balch WE, Wu G. J Biol Chem 286 20525-20535 (2011)
  21. ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate. Ma W, Goldberg E, Goldberg J. Elife 6 e26624 (2017)
  22. Nicotine-modulated subunit stoichiometry affects stability and trafficking of α3β4 nicotinic receptor. Mazzo F, Pistillo F, Grazioso G, Clementi F, Borgese N, Gotti C, Colombo SF. J Neurosci 33 12316-12328 (2013)
  23. COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers. Shomron O, Nevo-Yassaf I, Aviad T, Yaffe Y, Zahavi EE, Dukhovny A, Perlson E, Brodsky I, Yeheskel A, Pasmanik-Chor M, Mironov A, Beznoussenko GV, Mironov AA, Sklan EH, Patterson GH, Yonemura Y, Sannai M, Kaether C, Hirschberg K. J Cell Biol 220 e201907224 (2021)
  24. Disruption of the Sec24d gene results in early embryonic lethality in the mouse. Baines AC, Adams EJ, Zhang B, Ginsburg D. PLoS One 8 e61114 (2013)
  25. Akt phosphorylates Sec24: new clues into the regulation of ER-to-Golgi trafficking. Sharpe LJ, Luu W, Brown AJ. Traffic 12 19-27 (2011)
  26. An N-terminal dileucine motif directs two-pore channels to the tonoplast of plant cells. Larisch N, Schulze C, Galione A, Dietrich P. Traffic 13 1012-1022 (2012)
  27. The [corrected] SEC23-SEC31 [corrected] interface plays critical role for export of procollagen from the endoplasmic reticulum. Kim SD, Pahuja KB, Ravazzola M, Yoon J, Boyadjiev SA, Hammamoto S, Schekman R, Orci L, Kim J. J Biol Chem 287 10134-10144 (2012)
  28. Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells. Xiao C, Srinivasan R, Drenan RM, Mackey ED, McIntosh JM, Lester HA. Biochem Pharmacol 82 852-861 (2011)
  29. The secreted plant N-glycoproteome and associated secretory pathways. Ruiz-May E, Kim SJ, Brandizzi F, Rose JK. Front Plant Sci 3 117 (2012)
  30. Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2. Forrester A, Rathjen SJ, Daniela Garcia-Castillo M, Bachert C, Couhert A, Tepshi L, Pichard S, Martinez J, Munier M, Sierocki R, Renard HF, Augusto Valades-Cruz C, Dingli F, Loew D, Lamaze C, Cintrat JC, Linstedt AD, Gillet D, Barbier J, Johannes L. Nat Chem Biol 16 327-336 (2020)
  31. Identification of rice cornichon as a possible cargo receptor for the Golgi-localized sodium transporter OsHKT1;3. Rosas-Santiago P, Lagunas-Gómez D, Barkla BJ, Vera-Estrella R, Lalonde S, Jones A, Frommer WB, Zimmermannova O, Sychrová H, Pantoja O. J Exp Bot 66 2733-2748 (2015)
  32. News and Views into the SNARE Complexity in Arabidopsis. Kim SJ, Brandizzi F. Front Plant Sci 3 28 (2012)
  33. Endoplasmic reticulum stress reduces the export from the ER and alters the architecture of post-ER compartments. Amodio G, Renna M, Paladino S, Venturi C, Tacchetti C, Moltedo O, Franceschelli S, Mallardo M, Bonatti S, Remondelli P. Int J Biochem Cell Biol 41 2511-2521 (2009)
  34. Mutations in the COPII vesicle component gene SEC24B are associated with human neural tube defects. Yang XY, Zhou XY, Wang QQ, Li H, Chen Y, Lei YP, Ma XH, Kong P, Shi Y, Jin L, Zhang T, Wang HY. Hum Mutat 34 1094-1101 (2013)
  35. Mammalian COPII coat component SEC24C is required for embryonic development in mice. Adams EJ, Chen XW, O'Shea KS, Ginsburg D. J Biol Chem 289 20858-20870 (2014)
  36. An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin. Frazier SJ, Cohen BN, Lester HA. J Biol Chem 288 21029-21042 (2013)
  37. Sec24C/D-isoform-specific sorting of the preassembled ER-Golgi Q-SNARE complex. Adolf F, Rhiel M, Reckmann I, Wieland FT. Mol Biol Cell 27 2697-2707 (2016)
  38. The COPII cargo adapter SEC24C is essential for neuronal homeostasis. Wang B, Joo JH, Mount R, Teubner BJW, Krenzer A, Ward AL, Ichhaporia VP, Adams EJ, Khoriaty R, Peters ST, Pruett-Miller SM, Zakharenko SS, Ginsburg D, Kundu M. J Clin Invest 128 3319-3332 (2018)
  39. THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy. Li C, Chi H, Deng S, Wang H, Yao H, Wang Y, Chen D, Guo X, Fang JY, He F, Xu J, Xu J. J Immunother Cancer 9 e002443 (2021)
  40. Transport of the GlcNAc-1-phosphotransferase α/β-subunit precursor protein to the Golgi apparatus requires a combinatorial sorting motif. Franke M, Braulke T, Storch S. J Biol Chem 288 1238-1249 (2013)
  41. Dimeric sorting code for concentrative cargo selection by the COPII coat. Nie C, Wang H, Wang R, Ginsburg D, Chen XW. Proc Natl Acad Sci U S A 115 E3155-E3162 (2018)
  42. Sec23a mediates miR-200c augmented oligometastatic to polymetastatic progression. Sun Z, Zhou S, Tang J, Ye T, Li J, Liu D, Zhou J, Wang J, Rosie Xing H. EBioMedicine 37 47-55 (2018)
  43. A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C. Otsu W, Kurooka T, Otsuka Y, Sato K, Inaba M. J Biol Chem 288 18521-18532 (2013)
  44. A positive signal prevents secretory membrane cargo from recycling between the Golgi and the ER. Fossati M, Colombo SF, Borgese N. EMBO J 33 2080-2097 (2014)
  45. Cargo crowding contributes to sorting stringency in COPII vesicles. Gomez-Navarro N, Melero A, Li XH, Boulanger J, Kukulski W, Miller EA. J Cell Biol 219 e201806038 (2020)
  46. Endomembrane trafficking protein SEC24A regulates cell size patterning in Arabidopsis. Qu X, Chatty PR, Roeder AH. Plant Physiol 166 1877-1890 (2014)
  47. Differential selection of Golgi proteins by COPII Sec24 isoforms in procyclic Trypanosoma brucei. Demmel L, Melak M, Kotisch H, Fendos J, Reipert S, Warren G. Traffic 12 1575-1591 (2011)
  48. Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum. Lu CL, Ortmeier S, Brudvig J, Moretti T, Cain J, Boyadjiev SA, Weimer JM, Kim J. Traffic 23 81-93 (2022)
  49. Epsin N-terminal homology domains bind on opposite sides of two SNAREs. Wang J, Gossing M, Fang P, Zimmermann J, Li X, von Mollard GF, Niu L, Teng M. Proc Natl Acad Sci U S A 108 12277-12282 (2011)
  50. Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA. Thanabalasuriar A, Bergeron J, Gillingham A, Mimee M, Thomassin JL, Strynadka N, Kim J, Gruenheid S. Cell Microbiol 14 1206-1218 (2012)
  51. Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry. Yin P, Li Y, Zhang L. J Virol 91 e00629-17 (2017)
  52. Glucocorticoid Treatment Leads to Aberrant Ion and Macromolecular Transport in Regenerating Zebrafish Fins. Schmidt JR, Geurtzen K, von Bergen M, Schubert K, Knopf F. Front Endocrinol (Lausanne) 10 674 (2019)
  53. Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export. Gomez-Navarro N, Maldutyte J, Poljak K, Peak-Chew SY, Orme J, Bisnett BJ, Lamb CH, Boyce M, Gianni D, Miller EA. Proc Natl Acad Sci U S A 119 e2202080119 (2022)
  54. Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a. Spear JM, Koborssy DA, Schwartz AB, Johnson AJ, Audhya A, Fadool DA, Stagg SM. BMC Biochem 16 16 (2015)
  55. Regulated oligomerization induces uptake of a membrane protein into COPII vesicles independent of its cytosolic tail. Springer S, Malkus P, Borchert B, Wellbrock U, Duden R, Schekman R. Traffic 15 531-545 (2014)
  56. The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif. Lin YC, Chen BM, Lu WC, Su CI, Prijovich ZM, Chung WC, Wu PY, Chen KC, Lee IC, Juan TY, Roffler SR. PLoS One 8 e75084 (2013)
  57. Japanese patient with Cole-carpenter syndrome with compound heterozygous variants of SEC24D. Takeyari S, Kubota T, Miyata K, Yamamoto K, Nakayama H, Yamamoto K, Ohata Y, Kitaoka T, Yanagi K, Kaname T, Ozono K. Am J Med Genet A 176 2882-2886 (2018)
  58. A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells. Jain Goyal M, Zhao X, Bozhinova M, Andrade-López K, de Heus C, Schulze-Dramac S, Müller-McNicoll M, Klumperman J, Béthune J. Life Sci Alliance 3 e202000714 (2020)
  59. Effect of simultaneously replacing putative TM6 and TM12 of human NBCe1-A with those from NBCn1 on surface abundance in Xenopus oocytes. Chen LM, Qin X, Moss FJ, Liu Y, Boron WF. J Membr Biol 245 131-140 (2012)
  60. Mutations in the main cytoplasmic loop of the GABA(A) receptor α4 and δ subunits have opposite effects on surface expression. Bracamontes JR, Li P, Akk G, Steinbach JH. Mol Pharmacol 86 20-27 (2014)
  61. S100A8 transported by SEC23A inhibits metastatic colonization via autocrine activation of autophagy. Sun Z, Zeng B, Liu D, Zhao Q, Wang J, Rosie Xing H. Cell Death Dis 11 650 (2020)
  62. Dual-targeting of Arabidopsis DMP1 isoforms to the tonoplast and the plasma membrane. Kasaras A, Kunze R. PLoS One 12 e0174062 (2017)
  63. GEF-effector interactions. Jackson CL. Cell Logist 4 e943616 (2014)
  64. Conserved electrostatic fields at the Ras-effector interface measured through vibrational Stark effect spectroscopy explain the difference in tilt angle in the Ras binding domains of Raf and RalGDS. Walker DM, Wang R, Webb LJ. Phys Chem Chem Phys 16 20047-20060 (2014)
  65. Distinct stages in the recognition, sorting, and packaging of proTGFα into COPII-coated transport vesicles. Zhang P, Schekman R. Mol Biol Cell 27 1938-1947 (2016)
  66. Murine SEC24D can substitute functionally for SEC24C during embryonic development. Adams EJ, Khoriaty R, Kiseleva A, Cleuren ACA, Tomberg K, van der Ent MA, Gergics P, Tang VT, Zhu G, Hoenerhoff MJ, O'Shea KS, Saunders TL, Ginsburg D. Sci Rep 11 21100 (2021)
  67. TMD1 domain and CRAC motif determine the association and disassociation of MxIRT1 with detergent-resistant membranes. Tan S, Zhang P, Xiao W, Feng B, Chen LY, Li S, Li P, Zhao WZ, Qi XT, Yin LP. Traffic 19 122-137 (2018)
  68. SARS-CoV-2 3CLpro whole human proteome cleavage prediction and enrichment/depletion analysis. Prescott L. Comput Biol Chem 98 107671 (2022)
  69. The fifth subunit in α3β4 nicotinic receptor is more than an accessory subunit. Crespi A, Plutino S, Sciaccaluga M, Righi M, Righi M, Borgese N, Fucile S, Gotti C, Colombo SF. FASEB J 32 4190-4202 (2018)
  70. Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum. Wouters R, Michiels C, Sannerud R, Kleizen B, Dillen K, Vermeire W, Ayala AE, Demedts D, Schekman R, Annaert W. J Cell Biol 220 e201911104 (2021)
  71. Morpho-functional architecture of the Golgi complex of neuroendocrine cells. Martínez-Alonso E, Tomás M, Martínez-Menárguez JA. Front Endocrinol (Lausanne) 4 41 (2013)
  72. Novel Genetic and Phenotypic Expansion in GOSR2-Related Progressive Myoclonus Epilepsy. Hentrich L, Parnes M, Lotze TE, Coorg R, de Koning TJ, Nguyen KM, Yip CK, Jungbluth H, Koy A, Dafsari HS. Genes (Basel) 14 1860 (2023)
  73. Proteomic Analysis of Two Weight Classes of Mule Duck "foie gras" at the End of an Overfeeding Period. Lo B, Marty-Gasset N, Pichereaux C, Bravo C, Manse H, Domitile R, Rémignon H. Front Physiol 11 569329 (2020)
  74. The Metarhizium anisopliae Toxin, Destruxin A, Interacts with the SEC23A and TEME214 Proteins of Bombyx mori. Yin F, Xiao M, Berestetskiy A, Hu Q. J Fungi (Basel) 7 460 (2021)
  75. Case Reports A monoallelic SEC23A variant E599K associated with cranio-lenticulo-sutural dysplasia. Cisarova K, Garavelli L, Caraffi SG, Peluso F, Valeri L, Gargano G, Gavioli S, Trimarchi G, Neri A, Campos-Xavier B, Superti-Furga A. Am J Med Genet A 188 319-325 (2022)
  76. Ebola virus protein VP40 binding to Sec24c for transport to the plasma membrane. Bhattarai N, Pavadai E, Pokhrel R, Baral P, Hossen ML, Stahelin RV, Chapagain PP, Gerstman BS. Proteins 90 340-350 (2022)
  77. Identification of endoplasmic reticulum export motifs for G protein-coupled receptors. Wu G. Methods Enzymol 521 189-202 (2013)
  78. Regulation of EGFR surface levels by COPII-dependent trafficking. Farhan H. J Cell Biol 215 441-443 (2016)
  79. Opening up new fronts in the fight against cholesterol. Debose-Boyd RA, Horton JD. Elife 2 e00663 (2013)
  80. An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity. Almeida SM, Ivantsiv S, Niibori R, Dunham WH, Green BA, Zhao L, Gingras AC, Cordes SP. Dis Model Mech 16 dmm049762 (2023)
  81. DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Takahashi M, Chong HB, Zhang S, Yang TY, Lazarov MJ, Harry S, Maynard M, Hilbert B, White RD, Murrey HE, Tsou CC, Vordermark K, Assaad J, Gohar M, Dürr BR, Richter M, Patel H, Kryukov G, Brooijmans N, Alghali ASO, Rubio K, Villanueva A, Zhang J, Ge M, Makram F, Griesshaber H, Harrison D, Koglin AS, Ojeda S, Karakyriakou B, Healy A, Popoola G, Rachmin I, Khandelwal N, Neil JR, Tien PC, Chen N, Hosp T, van den Ouweland S, Hara T, Bussema L, Dong R, Shi L, Rasmussen MQ, Domingues AC, Lawless A, Fang J, Yoda S, Nguyen LP, Reeves SM, Wakefield FN, Acker A, Clark SE, Dubash T, Kastanos J, Oh E, Fisher DE, Maheswaran S, Haber DA, Boland GM, Sade-Feldman M, Jenkins RW, Hata AN, Bardeesy NM, Suvà ML, Martin BR, Liau BB, Ott CJ, Rivera MN, Lawrence MS, Bar-Peled L. Cell 187 2536-2556.e30 (2024)
  82. SEC24A stimulates oncogenicity of human gastric cancer cells. Lu M, Wang W, Zhang S, Li Y. Int J Clin Exp Pathol 11 4044-4051 (2018)
  83. A voyage from the ER: spatiotemporal insights into polarized protein secretion in neurons. Kersten N, Farías GG. Front Cell Dev Biol 11 1333738 (2023)
  84. TFG regulates inner COPII coat recruitment to facilitate anterograde secretory protein transport. Kasberg W, Luong P, Minushkin K, Pustova I, Swift KA, Zhao M, Audhya A. Mol Biol Cell 35 ar113 (2024)


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