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Crystal Structure of the Erythromycin Dehydratase

Source organism: Saccharopolyspora erythraea
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.3.1.94: 6-deoxyerythronolide-B synthase

Reaction catalysed:
Propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH = 6-deoxyerythronolide B + 7 CoA + 6 CO(2) + H(2)O + 6 NADP(+)
Systematic name:
Propanoyl-CoA:(2S)-methylmalonyl-CoA malonyltransferase (cyclizing)
Alternative Name(s):
  • 6-deoxyerythronolide B synthase
  • DEBS
  • Deoxyerythronolide B synthase
  • Erythronolide synthase
  • Erythronolide-condensing enzyme
  • Malonyl-CoA:propanoyl-CoA malonyltransferase (cyclizing)
  • Malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF14765
Domain description: Polyketide synthase dehydratase N-terminal domain
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4
The deposited structure of PDB entry 3el6 contains 1 copy of Pfam domain PF14765 (Polyketide synthase dehydratase N-terminal domain) in 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4. Showing 1 copy in chain A.

PF21089
Domain description: Polyketide synthase dehydratase domain
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4
The deposited structure of PDB entry 3el6 contains 1 copy of Pfam domain PF21089 (Polyketide synthase dehydratase domain) in 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR020807
Domain description: Polyketide synthase, dehydratase domain
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4
IPR042104
Domain description: Polyketide synthase, dehydratase domain superfamily
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4
IPR038052
Domain description: Chaperonin-like RbcX superfamily
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4

Structure domain

CATH CATH domain
3.10.129.110
Class: Alpha Beta
Architecture: Roll
Topology: Thiol Ester Dehydrase; Chain A
Homology: Polyketide synthase dehydratase
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4
The deposited structure of PDB entry 3el6 contains 1 copy of CATH domain 3.10.129.110 (Thiol Ester Dehydrase; Chain A) in 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4. Showing 1 copy in chain A.

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