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Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a ternary complex with products

Source organism: Homo sapiens
Biochemical function: decanoate-CoA ligase activity
Biological process: triglyceride homeostasis
Cellular component: mitochondrial matrix

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EC 6.2.1.25: Benzoate--CoA ligase

Reaction catalysed:
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA
Systematic name:
Benzoate:CoA ligase (AMP-forming)
Alternative Name(s):
  • Benzoate--coenzyme A ligase
  • Benzoyl CoA synthetase (AMP forming)
  • Benzoyl-coenzyme A synthetase

EC 6.2.1.2: Medium-chain acyl-CoA ligase

Reaction catalysed:
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA
Systematic name:
Medium-chain fatty acid:CoA ligase (AMP-forming)
Alternative Name(s):
  • Acyl-activating enzyme
  • Butanoate:CoA ligase (AMP-forming)
  • Butyryl-CoA synthetase
  • Butyryl-coenzyme A synthetase
  • FadK (gene name)
  • Fatty acid activating enzyme
  • Fatty acid elongase
  • Fatty acid thiokinase (medium chain)
  • Fatty acyl coenzyme A synthetase
  • L-(+)-3-hydroxybutyryl CoA ligase
  • LvaE (gene name)
  • Medium chain acyl-CoA synthetase
  • Short-chain acyl-CoA synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF13193
Domain description: AMP-binding enzyme C-terminal domain
Occurring in:
  1. Acyl-coenzyme A synthetase ACSM2A, mitochondrial
The deposited structure of PDB entry 3eq6 contains 2 copies of Pfam domain PF13193 (AMP-binding enzyme C-terminal domain) in Acyl-coenzyme A synthetase ACSM2A, mitochondrial. Showing 1 copy in chain A.

PF00501
Domain description: AMP-binding enzyme
Occurring in:
  1. Acyl-coenzyme A synthetase ACSM2A, mitochondrial
The deposited structure of PDB entry 3eq6 contains 2 copies of Pfam domain PF00501 (AMP-binding enzyme) in Acyl-coenzyme A synthetase ACSM2A, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR025110
Domain description: AMP-binding enzyme, C-terminal domain
Occurring in:
  1. Acyl-coenzyme A synthetase ACSM2A, mitochondrial
IPR045851
Domain description: AMP-binding enzyme, C-terminal domain superfamily
Occurring in:
  1. Acyl-coenzyme A synthetase ACSM2A, mitochondrial
IPR020845
Domain description: AMP-binding, conserved site
Occurring in:
  1. Acyl-coenzyme A synthetase ACSM2A, mitochondrial
IPR000873
Domain description: AMP-dependent synthetase/ligase domain
Occurring in:
  1. Acyl-coenzyme A synthetase ACSM2A, mitochondrial
IPR042099
Domain description: ANL, N-terminal domain
Occurring in:
  1. Acyl-coenzyme A synthetase ACSM2A, mitochondrial

Structure domains

CATH CATH domains
3.30.300.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GMP Synthetase; Chain A, domain 3
Homology: GMP Synthetase; Chain A, domain 3
Occurring in:
  1. Acyl-coenzyme A synthetase ACSM2A, mitochondrial
The deposited structure of PDB entry 3eq6 contains 2 copies of CATH domain 3.30.300.30 (GMP Synthetase; Chain A, domain 3) in Acyl-coenzyme A synthetase ACSM2A, mitochondrial. Showing 1 copy in chain A.
3.40.50.12780
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: N-terminal domain of ligase-like
Occurring in:
  1. Acyl-coenzyme A synthetase ACSM2A, mitochondrial
The deposited structure of PDB entry 3eq6 contains 2 copies of CATH domain 3.40.50.12780 (Rossmann fold) in Acyl-coenzyme A synthetase ACSM2A, mitochondrial. Showing 1 copy in chain A.

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