Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to form C5a and C5b.
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Complement C2a fragment (preferred)
PDBe Complex ID:
PDB-CPX-139130 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement C2b fragment
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1
Length: 223 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P06681 (Residues: 21-243; Coverage: 31%)
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU
Spacegroup:
P31
Expression system: Trichoplusia ni
